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Fasn-1 regulates antimicrobial peptide (show cAMP Proteins) nlp-29 expression in a WNK-1 (show WNK1 Proteins) and gck (show GCK Proteins)-3 dependent manner.
Genetic interactions at the cell-autonomous level, where glycolytic enzymes or Glo1 (show GLO1 Proteins) were manipulated in FASN mutant cells, revealed that this sugar-dependent size reduction is a direct consequence of MG-derived-AGE accumulation
These findings implicate Spot14 (show THRSP Proteins) as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.
High FASN expression is associated with prostate cancer growth.
We show that elevated levels of PPARG (show PPARG Proteins) strongly correlate with elevation of FASN in human prostate cancer (CaP) and that high levels of PPARG (show PPARG Proteins)/FASN and PI3K (show PIK3CA Proteins)/pAKT (show AKT1 Proteins) pathway activation confer a poor prognosis.These data suggest that CaP patients could be stratified in terms of PPARG (show PPARG Proteins)/FASN and PTEN levels to identify patients with aggressive CaP who may respond favorably to PPARG (show PPARG Proteins)/FASN inhibition.
High FASN expression is associated with meningioma and schwannoma.
our findings show that microRNA-195 inhibits pancreatic cancer cell proliferation and invasion by regulating the fatty acid synthase/Wnt (show WNT2 Proteins) signaling pathway, suggesting a tumor suppressive role for microRNA-195 in the development and progression of pancreatic cancer. Thus, inhibiting fatty acid synthase by microRNA-195 may serve as a novel therapeutic approach for the treatment of pancreatic cancer.
Inhibition of FASN can decrease the levels of IGFBP1 (show IGFBPI Proteins), and the expression, activity, and ubiquitination of HIF-1alpha (show HIF1A Proteins). Inhibition of FASN can suppress migration, invasion and healing of hepatoma carcinoma cells by decreasing HIF-1alpha (show HIF1A Proteins), and IGFBP1 (show IGFBPI Proteins).
The involvement of SREBP-1c (show SREBF1 Proteins) and ChREBP (show MLXIPL Proteins) in FASN promoter histone modification.Histone acetylation affects FASN transcription by influencing ChREBP (show MLXIPL Proteins)-binding carbohydrate-responsive elements.
Fatty acid synthase (FASN) inhibitors reduce proliferation and promote apoptosis in high FASN producers lymphatic endothelial cells (HDLEC) cells.
MACC1 (show MACC1 Proteins) and FASN are positively correlated and responsible for the poor prognoses in gastric cancer patients.FASN role in gastric cancer resistance to oxaliplatin.
Fatty acid synthase fine-tunes the cell's response to stress and injury by remodeling cellular O-GlcNAcylation
FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 (show INSIG2 Proteins) is a promising marker for FA composition
In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation (show HELLS Proteins) status in the inner layer of backfat from Jinhua pigs at different developmental stages.
calculated a 4.5 angstrom-resolution map of fatty acid synthase, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density
study determined fatty acid synthase crystal structure at 3.2 angstrom resolution covering five catalytic domains; structure reveals a complex architecture of alternating linkers and enzymatic domains
FASN regulates the pathogenicity of Th17 cells.
genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice.
Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states.
study demonstrates that co-activation of AKT (show AKT1 Proteins) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN pathway.
Inhibition of G-protein-coupled Receptor Kinase 2 (show ADRBK1 Proteins) Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
These findings suggest that activation of TSHR (show TSHR Proteins) directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK (show EPHB2 Proteins)
UCP2 (show UCP2 Proteins)-induced fatty acid synthase promotes NLRP3 (show NLRP3 Proteins) inflammasome activation during sepsis
FASN plays an important role in exercise-mediated cognitive enhancement, which might be associated to its role in modulating exercise-induced stimulation of neurogenesis.
FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland.
Gamma-tocotrienol showed attenuation of triglyceride through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1 (show SREBF1 Proteins), stearoyl CoA desaturase 1 (show SCD Proteins), and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6 cells.
FASN single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle.
Results indicate that Fatty acid synthase (FASN) may be used as a candidate gene affecting intramuscular fat content in Datong yaks.
It was suggested that two cattle breeds have an advantage in terms of genotype and haplotype distribution of the FASN gene; a single polymorphism might be a potential marker for breed discrimination.
study evaluated the contributions of polymorphisms of FASN and SCD (show SCD Proteins) genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations
The five exonic single nucleotide polymorphisms of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents.
Results suggest that SCD (show SCD Proteins) and FASN are strong candidate genes influencing fatty acid composition in beef cattle.
The effects of genetic polymorphisms of liver X receptor, alpha (LXR (show NR1H3 Proteins)), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
In ruminants, FASN may be regulated between the ratio between two transcripts. The small transcript is mostly produced in tissues with low fatty acid synthesis.
Polymorphisms within the FASN gene are associated with milk-fat content.
The results suggested that LXR (show NR1H3 Proteins) regulates FASN promoter activity through direct interaction with the LXR (show NR1H3 Proteins) response element as well as through increasing SREBP1 (show SREBF1 Proteins) abundance.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
fatty acid synthase
, fatty acid synthase Fas
, Fatty acid synthase Fas
, Fatty Acid SyNthase family member (fasn-1)
, fatty-acid synthase
, fatty-acid synthase II
, fatty-acid synthase fas
, fatty acid synthetase
, short chain dehydrogenase/reductase family 27X, member 1