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anti-Mouse (Murine) HNF4A Antibodies:
anti-Rat (Rattus) HNF4A Antibodies:
anti-Human HNF4A Antibodies:
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Cow (Bovine) Polyclonal HNF4A Primary Antibody for WB - ABIN2777514
Weedon, Owen, Shields, Hitman, Walker, McCarthy, Love-Gregory, Permutt, Hattersley, Frayling: Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population. in Diabetes 2004
Show all 4 Pubmed References
Human Polyclonal HNF4A Primary Antibody for ELISA, WB - ABIN4319471
Huang, Karakucuk, Levitsky, Rhoads: Expression of HNF4alpha variants in pancreatic islets and Ins-1 beta cells. in Diabetes/metabolism research and reviews 2008
Show all 4 Pubmed References
Human Polyclonal HNF4A Primary Antibody for IHC, IHC (p) - ABIN4319472
Mezentsev, Amundson: Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model. in Radiation research 2011
Show all 2 Pubmed References
Human Polyclonal HNF4A Primary Antibody for IHC (fro), IHC (p) - ABIN3043844
Dai, Cai, Wu, Chen, Han: Protocatechuic acid inhibits hepatitis B virus replication by activating ERK1/2 pathway and down-regulating HNF4α and HNF1α in vitro. in Life sciences 2017
Human Polyclonal HNF4A Primary Antibody for ELISA, WB - ABIN547423
Damcott, Hoppman, Ott, Reinhart, Wang, Pollin, OConnell, Mitchell, Shuldiner: Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. in Diabetes 2004
Human Polyclonal HNF4A Primary Antibody for IHC (p), WB - ABIN317780
Hu, Ma, Huang, Mao, Yang, Zhao, Li, Qiu, Yang, Zheng, Wang: Dihydrocapsaicin Attenuates Plaque Formation through a PPAR?/LXR? Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet. in PLoS ONE 2013
Human Polyclonal HNF4A Primary Antibody for PLA, WB - ABIN516575
Furumiya, Inoue, Ohta, Hayashi, Yuasa: Transcriptional regulation of PCFT by KLF4, HNF4?, CDX2 and C/EBP?: implication in its site-specific expression in the small intestine. in Biochemical and biophysical research communications 2013
Here the authors report that loss of Drosophila HNF4 recapitulates hallmark symptoms of Maturity Onset Diabetes of the Young 1 (MODY1), including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin secretion (GSIS).
Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.
Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.
the tight conjunction of G4s and an adjacent stem-loop within the Hnf4a1 5' UTR was both necessary and sufficient to mediate the very strong translational repression.
PRMT1 inhibition, such as induced by alcohol, may result in epigenetic changes leading to loss of Hnf4alpha. This effect may contribute to alcohol's ability to promote liver tumors
this study shows that diabetes-linked transcription factor HNF4alpha regulates maminotransferase 2etabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate
These results indicate a critical and conserved role for HNF4A in maintaining intestinal homeostasis in response to microbiota.
HNF4alpha is required for recruitment of the HDAC3-PROX1 module in liver.
In summary, HNF4alpha isoforms perform non-redundant functions in the colon under conditions of stress, underscoring the importance of tracking them both in colitis and colon cancer.
Hnf4alpha silencing with shRNA transfection into auditory neuroblast cells (VOT-33) reduced cell viability
both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR-122.
Tg737 regulates a Wnt/beta-catenin/Snail-HNF4alpha negative feedback circuit, thereby blocking EMT and the malignant transformation of liver stem cells to liver cancer stem cells.
Down regulation of HNF4 alpha plays a role in metabolic liver function and the pathogenesis of liver cancer.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha in human biopsy samples.
Fibrotic levels of matrix stiffness significantly inhibit hepatocyte-specific functions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-associated protein kinase pathway.
key role in controlling hepatic CES2 expression in diabetes, obesity, or nonalcoholic steatohepatitis
These findings reveal a novel HNF4alpha network controlled by miR-194/192 that may play a critical role in maintaining the hepatocyte-differentiated state by inhibiting expression of genes involved in dedifferentiation and tumorigenesis.
HNF4alpha regulates homeostatic proliferation in the gastric epithelium and is both necessary and sufficient for the upstream regulation of the Xbp1-->Mist1 axis in maintenance of zymogen cell secretory architecture.
These results suggest that down-regulation of HNF4alpha could be of importance in beta-cell dysfunction by hypoxia.
Hnf4a expression during embryonic stem cell differentiation
Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha.
HNF-4alpha regulated miR-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells
The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP transcription in response to glucose, and also demonstrated that ChREBP-alpha and HNF-4alpha synergistically increased ChREBP-beta transcription.
The two isoforms of HNF4Alpha, which are differentially expressed in liver cancer, exhibit distinct circadian roles.
genetic association studies in population of children in Japan: Data suggest that mutations in INS, HNF1A, HNF4A, and HNF1B likely play critical roles in children with insulin-requiring autoantibody-negative type 1 diabetes in the population studied. (INS = insulin; HNF1A = HNF1 homeobox A; HNF4A = hepatocyte nuclear factor 4 alpha; HNF1B = HNF1 homeobox B)
Our findings highlight the regulatory networks among TFs, lncRNAs, miRNAs, and mRNAs in hepatocellular carcinoma (HCC). Several key molecules, such as hsa-miR-195, lncRNA MALAT1 and TFs TAF1 and HNF4alpha, may contribute to the progression of HCC.
Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant
DDX3 regulates MTP gene expression and lipid homeostasis through interplay with HNF4 and SHP.
These findings suggest that GATA6 might interact with HNF4alpha and contribute to the development of mucinous-type lung adenocarcinomas
HNF4-alpha and particularly SATB2 may be helpful in the differential diagnosis of pulmonary adenocarcinoma and metastases of colorectal adenocarcinomas
Study identified for the first time that HNF4alpha and C/EBPalpha are important transcriptional regulators for FBP1 expression in human hepatoma HepG2 cells.
Although DNA methylation (5mC) and hydroxymethylation (5hmC) are highly dynamic during early embryonic development, less is known about their roles at later stages of differentiation. 5hmC marks HNF4A promoter 1 previous to terminal hepatocyte differentiation. TET1-dependent 5hmC is required to activate promoter 1-driven HNF4A expression.
HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis
This work suggested that OA increased PKM1/PKM2 ratio, resulting in HNF-4alpha activation and hepatoma differentiation.
HNF-4A plays a critical role in lipid and glucose homeostasis in second trimester of pregnancy
this is the first report to clarify the expression pattern and function of HNF4alpha during the definitive endoderm differentiation.
HNF4A is central to the pathogenesis of NASH. This adds to previous literature demonstrating that HNF4A regulates the transcription of genes involved in the progression of NAFLD, and that HNF4A genetic variants play a potential role in NASH progression
Specifically tested on two model systems, the power of iSPOT is demonstrated to accurately predict the structures of a large protein-protein complex (TGFbeta-FKBP12) and a multidomain nuclear receptor homodimer (HNF-4alpha), based on the structures of individual components of the complexes.
Apoptosis signal-regulating kinase 1 (ASK1) expression was dramatically suppressed and correlated with hepatocyte nuclear factor 4alpha (HNF4alpha) levels in hepatocellular carcinoma (HCC) tissues.
2, 3-dihydroquinazolinone derivative, DHQZ-17, potently inhibited the expression of HNF4A, suppressing tumorigenicity of head and neck squamous cell carcinoma in vivo.
Examination of clinical samples revealed that HNF4alpha and IL-1R1 levels increase with increasing severity of Hp-induced gastritis and reach their highest levels in Gastric Carcinoma. Co-expression of HNF4alpha and IL-1R1 was a crucial indicator of malignant transformation from gastritis to GC.
HCV-related HCC could be mediated through HNF4alpha-microRNA deregulation
HNF4 positively regulates pUPII gene promoter activity.
Tetra-primer ARMS-PCR identifies the novel genetic variations of bovine HNF-4alpha gene associating with growth traits.
Results show that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor 1A promoter activity through binding to a common DNA element
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
hepatocyte nuclear factor 4 alpha
, hepatocyte nuclear factor 4, alpha
, hepatocyte nuclear factor 4-alpha-like
, hepatocyte nuclear factor 4-alpha
, hepatocyte nuclear factor 4
, hepatocyte nuclear factor 4 homologue
, HNF4 alpha
, Nuclear receptor 2A1
, nuclear receptor subfamily 2 group A member 1
, transcription factor 14
, transcription factor HNF-4
, alpha transcription factor 4
, hepatic nuclear factor 4, alpha
, hepatic nuclear factor 4 alpha
, hepatic nuclear factor 4
, hepatic nuclear factor 4alpha
, nuclear receptor