NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (C-Term)

Details for Product anti-NFKBIB Antibody No. ABIN100659
Antigen
Epitope
C-Term
51
21
15
12
8
7
7
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
230
128
107
10
8
8
7
5
4
1
1
1
Host
Rabbit
197
35
Clonality
Polyclonal
Conjugate
This NFKBIB antibody is un-conjugated
10
8
8
8
8
8
8
4
4
2
2
2
2
2
2
2
1
Application
Western Blotting (WB)
150
88
81
31
28
24
8
7
6
5
3
2
1
Options
Immunogen IkBb peptide corresponding to a region near the of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Purification Antiserum
Sterility Sterile filtered
Antigen
Alternative Name IKB beta (NFKBIB Antibody Abstract)
Background NFkB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells.  It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.
Synonyms: NF kappa BIB antibody, NFKBIB antibody, Thyroid receptor interacting protein 9 antibody, TR interacting protein 9 antibody, TRIP9 antibody
Gene ID 4793
UniProt Q15653
Pathways NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
Application Notes This product was assayed by immunoblot and found to be reactive against IkBb at a dilution of 1:1000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] Goat) Anti- IkBb is suitable for the detection by immunoblot of human, mouse and rat IkBb. 
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta (NFKBIB) (C-Term) antibody (ABIN100659) Western Blot of Rabbit Anti-IKB Beta C-term Antibody. Lane 1: Opal Prestained Molecul...