IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (C-Term)

Details for Product anti-IKBKB Antibody No. ABIN100667
Antigen
Epitope
C-Term
65
39
26
21
19
18
18
18
18
18
18
18
17
17
17
17
17
17
17
15
15
8
8
7
7
4
4
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
640
230
203
22
14
13
7
6
5
4
1
1
Host
Rabbit
583
71
9
2
Clonality
Polyclonal
Conjugate
This IKBKB antibody is un-conjugated
42
39
39
32
31
31
9
9
9
8
8
8
6
6
6
6
6
Application
Western Blotting (WB)
338
287
244
116
79
63
46
27
18
9
7
6
5
3
2
1
Options
Immunogen IKKb peptide corresponding to the highly conserved of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Characteristics Concentration Definition: by Refractometry
Purification Antiserum
Sterility Sterile filtered
Antigen
Alternative Name IKK beta (IKBKB Antibody Abstract)
Background NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death.  In the cytoplasm NFkB is negatively modulated by the inhibitory proteins IkB.  In turn IkB is phosphorylated by a cellular kinase complex called IKK.  IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate IkB leading to its degradation and the resulting translocation of NFkB to the nucleus.  IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF- a, endotoxins and overexpression of cellular kinases like MEKK1.  Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.
Synonyms: Inhibitor of nuclear factor kappa-B kinase subunit beta I-kappa-B-kinase beta, IkBKB, IKK-beta, IKK-B EC=2.7.11.10 I-kappa-B kinase 2 IKK2 Nuclear factor NF-kappa-B inhibitor kinase beta NFKBIKB
Gene ID 3551
UniProt O14920
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes This product was assayed by immunoblot and found to be reactive against IKKb at a dilution of 1:1000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] Goat) Anti- IKKb is suitable for the detection by immunoblot of human, mouse and rat IKKb showing an 87 kDa band.  This product was assayed by immunoblot and found to be reactive against IKKb at a dilution of 1:1000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat) Anti- IKKb is suitable for the detection by immunoblot of human, mouse and rat IKKb showing an 87 kDa band. 
Restrictions For Research Use only
Format Liquid
Concentration 80 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (C-Term) antibody (ABIN100667) Western blot of anti-IKKß antibody reacted with HeLa cell extract. All incubations ex...
Image no. 2 for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (C-Term) antibody (ABIN100667) Anti-IKKß antibody was diluted 1:500 to detect IKKß in human placenta tissue. Tissue ...