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CD79b antibody (FITC)

CD79B Reactivity: Human FACS Host: Mouse Monoclonal CB3-1 FITC
Catalog No. ABIN1027695
  • Target See all CD79b (CD79B) Antibodies
    CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
    Reactivity
    • 115
    • 47
    • 18
    • 6
    • 6
    Human
    Host
    • 63
    • 48
    • 13
    • 9
    • 4
    • 2
    Mouse
    Clonality
    • 75
    • 58
    • 1
    Monoclonal
    Conjugate
    • 70
    • 16
    • 14
    • 11
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD79b antibody is conjugated to FITC
    Application
    • 73
    • 72
    • 40
    • 37
    • 33
    • 14
    • 13
    • 11
    • 11
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Fraction of Ig-associated molecules isolated from Ramos B cells
    Clone
    CB3-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD79B Primary Antibody
  • Application Notes
    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
    Comment

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Avoid prolonged exposure to light.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Dornan, Bennett, Chen, Dennis, Eaton, Elkins, French, Go, Jack, Junutula, Koeppen, Lau, McBride, Rawstron, Shi, Yu, Yu, Yue, Zheng, Ebens, Polson: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." in: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).

    Zheng, Fuji, Elkins, Yu, Fuh, Chuh, Tan, Hongo, Raab, Kozak, Williams, McDorman, Eaton, Ebens, Polson: "In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates." in: Molecular cancer therapeutics, Vol. 8, Issue 10, pp. 2937-46, (2009) (PubMed).

    Matutes: "New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders." in: Journal of clinical pathology, Vol. 55, Issue 3, pp. 180-3, (2002) (PubMed).

    DArena, Cascavilla, Musto, Colella Bisogno, Pistolese, Carotenuto: "CD79b expression in B-cell chronic lymphocytic leukemia." in: Haematologica, Vol. 85, Issue 5, pp. 556-7, (2000) (PubMed).

    Rassenti, Kipps: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).

    Nakamura, Kubagawa, Cooper: "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8522-6, (1992) (PubMed).

  • Target
    CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
    Alternative Name
    CD79b (CD79B Products)
    Synonyms
    B29 antibody, Ig-beta antibody, Igb antibody, Igbeta antibody, AGM6 antibody, IGB antibody, CD79B antigen antibody, CD79b molecule antibody, Cd79b antibody, CD79B antibody
    Background
    CD79b molecule,CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR beta, Ig-beta, B29, IGB
    Gene ID
    974
    UniProt
    P40259
    Pathways
    BCR Signaling
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