beta Amyloid antibody (Amyloid beta) (N-Term)

Details for Product anti-Abeta Antibody No. ABIN1043866, Supplier: Log in to see
Antigen
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • Abeta
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • amyloid beta precursor protein
  • amyloid beta (A4) precursor protein
  • APP
  • app
  • App
Epitope
N-Term
70
36
26
12
11
6
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
239
57
41
19
11
9
8
6
5
5
4
4
3
3
3
3
2
2
1
Host
Rabbit
186
77
6
1
Clonality
Polyclonal
Conjugate
This beta Amyloid antibody is un-conjugated
16
7
6
4
4
4
4
4
4
4
4
4
3
3
3
3
2
2
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
173
148
82
73
71
59
32
22
11
5
5
3
3
2
2
2
2
1
1
1
1
1
Options
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Immunogen This antibody was affinity purified from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to the amino terminus (aa 1-14) of human beta amyloid conjugated to KLH using maleimide.
Immunogen Type: Peptide
Isotype IgG
Specificity This affinity-purified antibody is directed against the amino terminal end of beta amyloid and is useful in determining its presence in various assays. Polyclonal anti-beta amyloid detects human and mouse beta amyloid. Cross reactivity with beta amyloid from other species is likely but has not been determined.
Characteristics Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.
Purification affinity purified
Sterility Sterile filtered
Alternative Name Beta Amyloid (Abeta Antibody Abstract)
Background Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.
Synonyms: Beta amyloid, A-beta
Gene ID 351
NCBI Accession NP_000475
UniProt P05067
Application Notes Affinity purified anti-beta amyloid detects beta amyloid in ELISA, IHC and IF. A 40-50 kD band consistent with a higher MW precursor is detected in western blot using whole tissue extracts from mouse brain. In general, we recommend the use of 4% PFA for paraffin embedded tissues and 10% formalin for frozen tissue for fixation.
Comment

Gene Name: APP

Restrictions For Research Use only
Format Liquid
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Expiry Date 12 months
Supplier Images
 image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) anti-Amyloid beta (Abeta) (N-Term) antibody
 image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) anti-Amyloid beta (Abeta) (N-Term) antibody (Image 2)
 image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) anti-Amyloid beta (Abeta) (N-Term) antibody (Image 3)
ELISA image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) ELISA results of purified Rabbit anti-Beta Amyloid Antibody tested against BSA-conjug...
Immunofluorescence (IF) image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Immunofluorescence microscopy of Rabbit Anti-Beta Amyloid antibody using HeLa cells f...
Immunofluorescence (IF) image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Immunohistochemistical detection of beta Amyloid using Anti-Beta Amyloid Antibody on ...
Western Blotting (WB) image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Mouse Brain (Lane 1) and Mouse Spinal Chord (Lane 2) were run on a 4-20% gradient gel...
Western Blotting (WB) image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Western Blot of Rabbit anti-Beta Amyloid Antibody. Lane 1: HEK293 WCL. Lane 2: Mouse ...
Western Blotting (WB) image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Western Blot of Rabbit anti-Beta Amyloid antibody. Marker: Opal Pre-stained ladder . ...
 image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Human Heart (formalin-fixed, paraffin-embedded) stained with Anti-Beta Amyloid Antibo...
Immunohistochemistry (IHC) image for anti-Amyloid beta (Abeta) (N-Term) antibody (ABIN1043866) Immunohistochemistry with anti-beta amyloid antibody showing amyloid beta plaque stai...
Product cited in: Frenkel, Balass, Solomon: "N-terminal EFRH sequence of Alzheimer's beta-amyloid peptide represents the epitope of its anti-aggregating antibodies." in: Journal of neuroimmunology, Vol. 88, Issue 1-2, pp. 85-90, 1998 (PubMed).

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