HSPE1 antibody (AA 2-102) (FITC)

Catalog No. ABIN1045135

Product Details anti-HSPE1 Antibody (FITC)

Target: HSPE1 (Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1))

Binding Specificity: AA 2-102

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSPE1 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 10 kDa heat shock protein, mitochondrial protein (2-102AA)

Isotype: IgG

Application Details

Application Notes: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles. Product is photosensitive and should be protected from light.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HSPE1

Target: HSPE1 (Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1))

Alternative Name: HSPE1 (HSPE1 Products)

Background:

Background: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).

Aliases: 10 kDa chaperonin antibody, 10 kDa heat shock protein mitochondrial antibody, 10 kDa heat shock protein, mitochondrial antibody, CH10_HUMAN antibody, Chaperonin 10 antibody, Chaperonin 10 homolog antibody, CPN10 antibody, cpn10 homolog antibody, Early pregnancy factor antibody, Early-pregnancy factor antibody, EPF antibody, GROES antibody, GroES homolog antibody, Heat shock 10kD protein 1 chaperonin 10 antibody, Heat shock 10 kDa protein 1 antibody, Heat shock 10 kDa protein 1 chaperonin 10 antibody, Heat shock protein family E (Hsp10) member antibody, Heat-shock 10-kD protein antibody, Hsp10 antibody, Hspe1 antibody

UniProt: P61604

Pathways: Positive Regulation of Endopeptidase Activity