ARPC2 antibody (AA 1-250) (FITC)

Catalog No. ABIN1045180

Product Details anti-ARPC2 Antibody (FITC)

Target: ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa (ARPC2))

Binding Specificity: AA 1-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARPC2 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Actin-related protein 2/3 complex subunit 2 protein (1-250AA)

Isotype: IgG

Application Details

Application Notes: Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles. Product is photosensitive and should be protected from light.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARPC2

Target: ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa (ARPC2))

Alternative Name: ARPC2 (ARPC2 Products)

Synonyms: arc34 antibody, p34-arc antibody, pnas-139 antibody, pro2446 antibody, Arpc2 antibody, Arc-p34 antibody, 2210023N03Rik antibody, 34kDa antibody, p34-Arc antibody, fk84a07 antibody, wu:fa22f07 antibody, wu:fk84a07 antibody, zgc:77769 antibody, ARC34 antibody, PNAS-139 antibody, actin related protein 2/3 complex subunit 2 antibody, actin related protein 2/3 complex, subunit 2, 34kDa antibody, actin related protein 2/3 complex, subunit 2 antibody, actin related protein 2/3 complex subunit 2 S homeolog antibody, ARPC2 antibody, arpc2 antibody, Arpc2 antibody, arpc2.S antibody

Background:

Background: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Aliases: Actin related protein 2/3 complex subunit 2 34 kDa antibody, Actin related protein 2/3 complex subunit 2 antibody, Actin-related protein 2/3 complex subunit 2 antibody, ARC 34 antibody, ARC34 antibody, Arp2/3 complex 34 kDa subunit antibody, ARP2/3 protein compex subunit 34 antibody, ARPC 2 antibody, Arpc2 antibody, ARPC2_HUMAN antibody, p34 Arc antibody, p34-ARC antibody, p34Arc antibody, PNAS 139 antibody, PNAS139 antibody, PRO 2446 antibody, PRO2446 antibody

UniProt: O15144

Pathways: RTK Signaling, Regulation of Actin Filament Polymerization