PLA1A antibody (C-Term)

Catalog No. ABIN1077384

Product Details anti-PLA1A Antibody

Target: PLA1A (Phospholipase A1 Member A (PLA1A))

Binding Specificity: C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: At least three isoforms of PLA1A are known to exist, this antibody will detect all three isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A.

Isotype: IgG

Application Details

Application Notes: PLA1A antibody can be used for detection of PLA1A by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Comment:

(CT) Phospholipase A1 member A

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: PLA1A antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for PLA1A

Target: PLA1A (Phospholipase A1 Member A (PLA1A))

Alternative Name: PLA1A (PLA1A Products)

Synonyms: PS-PLA1 antibody, PSPLA1 antibody, AA986889 antibody, Ps-pla1 antibody, Pspla1 antibody, wu:fi26h09 antibody, zgc:77160 antibody, AH antibody, ARWH2 antibody, LAH2 antibody, LPDLR antibody, PLA1B antibody, mPA-PLA1 antibody, phospholipase A1 member A antibody, lipase H antibody, PLA1A antibody, Pla1a antibody, pla1a antibody, CpipJ_CPIJ002492 antibody, CpipJ_CPIJ007883 antibody, LIPH antibody

Background: PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
Synonyms: Phospholipase A1 member A, phosphatidylserine-specific phospholipase A1, PS-PLA1

Molecular Weight: 50 kDa

Gene ID: 51365

NCBI Accession: NP_056984