CRB2 antibody

Catalog No. ABIN1077416

Product Details anti-CRB2 Antibody

Target: CRB2 (Crumbs Homolog 2 (CRB2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRB2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: At least three isoforms of CRB2 are known to exist, this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2.

Isotype: IgG

Application Details

Application Notes: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 - 2 μg/mL.

Comment:

(IN) Crumbs homolog 2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: CRB2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for CRB2

Target: CRB2 (Crumbs Homolog 2 (CRB2))

Alternative Name: CRB2 (CRB2 Products)

Synonyms: 5930402A21 antibody, BC043114 antibody, RGD1309368 antibody, crb2 antibody, crumbs family member 2 antibody, crumbs 2, cell polarity complex component antibody, crumbs family member 2a antibody, Crb2 antibody, CRB2 antibody, crb2a antibody

Background: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.
Synonyms: Crumbs homolog 2, crumbs 2, crumbs-like protein 2

Molecular Weight: 141 kDa (calculated)

Gene ID: 286204

NCBI Accession: NP_775960

Pathways: Notch Signaling