TNFSF4 antibody (C-Term)

Catalog No. ABIN1077446

Product Details anti-TNFSF4 Antibody

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TNFSF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least two isoforms of TNFSF4 are known to exist, this antibody will detect both isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal TNFSF4 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TNFSF4.

Isotype: IgG

Application Details

Application Notes: TNFSF4 antibody can be used for detection of TNFSF4 by Western blot at 0.5 - 1 μg/mL.

Comment:

(CT) Tumor necrosis factor ligand superfamily 4

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Target Details for TNFSF4

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Alternative Name: TNFSF4 (TNFSF4 Products)

Synonyms: TNFSF4 antibody, OX40L antibody, TNFRSF4 antibody, CD134L antibody, CD252 antibody, GP34 antibody, OX-40L antibody, OX4OL antibody, TXGP1 antibody, Ath-1 antibody, Ath1 antibody, Ox40l antibody, Txgp1l antibody, gp34 antibody, TNF superfamily member 4 antibody, tumor necrosis factor (ligand) superfamily, member 4 antibody, TNFSF4 antibody, Tnfsf4 antibody

Background: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
Synonyms: Tumor necrosis factor ligand superfamily 4, OX40L, GP34, TXGP1, CD134L, CD252

Molecular Weight: 20 kDa

Gene ID: 7292

NCBI Accession: NP_003317

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints