NGFR antibody (AA 202-215)

Catalog No. ABIN1103253

Product Details anti-NGFR Antibody

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Binding Specificity: AA 202-215

Reactivity: Human, Rat, Horse, Hamster

Host: Goat

Clonality: Polyclonal

Conjugate: This NGFR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Human NGFR. This antibody is expected to recognize the extracellular domain of p75NTR.

Predicted Reactivity: Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Rat, Hamster, Horse (100%) Gorilla, Gibbon, Monkey, Marmoset, Elephant, Bovine (93%) Galago, Mouse, Panda, Rabbit, Porcine (86%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide C-PEGSDSTAPSTQEP from an internal region of human NGFR (NP_002498.1). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Rat, Hamster, Horse (100%), Gorilla, Gibbon, Monkey, Marmoset, Elephant, Bovine (93%), Galago, Mouse, Panda, Rabbit, Porcine (86%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: Peptide-ELISA (1:4000), WB (1 - 3 μg/mL)

Usage: Peptide ELISA: antibody detection limit dilution 1:4000. Western blot: Approx 75kD band observed in Rat Heart lysates (calculated MW of 45.2kD according to Human NP_002498.1 and 45.4kD according to Rat NP_036742.2. The observed molecular weight corresponds to earlier findings in literature with different antibodies (Nykjaer et al, Curr Opin Neurobiol. 2005 Feb,15(1):49-57). Recommended concentration: 1-3 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Alternative Name: NGFR / CD271 / p75 (NGFR Products)

Synonyms: ngfr antibody, wu:fb38c02 antibody, wu:fc10h01 antibody, CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody, LNGFR antibody, RNNGFRR antibody, Tnfrsf16 antibody, p75 antibody, NRH1b antibody, fullback antibody, nrh1 antibody, p75ntr antibody, tnfrsf16 antibody, p75NGFR antibody, nerve growth factor receptor antibody, neurotrophin receptor associated death domain antibody, nerve growth factor receptor S homeolog antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, NGFR antibody, nradd antibody, Ngfr antibody, ngfr.S antibody

Background: Name/Gene ID: NGFR
Family: TNF Receptor

Synonyms: NGFR, CD271, CD271 antigen, gp80-LNGFR, Nerve growth factor receptor, p75 ICD, p75(NTR), p75NTR, TNFR superfamily, member 16, NGF receptor, TNFRSF16

Gene ID: 4804

NCBI Accession: NP_002498

UniProt: P08138

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding