AIFM1 antibody (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1)

Details for Product anti-AIFM1 Antibody No. ABIN1105269
Target
Reactivity
Human, Monkey, Mouse, Rat
123
71
70
24
14
13
9
8
8
7
5
4
4
2
1
1
Host
Mouse
112
11
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This AIFM1 antibody is un-conjugated
7
4
4
4
3
3
3
3
3
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
99
48
41
29
28
19
13
11
10
8
4
2
2
1
1
Options
Clone 4-00E-007
Isotype IgG2b
Specificity This antibody reacts to AIF.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Monkey and Rat.
Purification Ascites
Target
Alternative Name AIFM1 / AIF (AIFM1 Antibody Abstract)
Background This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10Synonyms: Apoptosis-inducing factor 1 mitochondrial, PDCD8, Programmed cell death protein 8
Molecular Weight 67 kDa
Gene ID 9131
Pathways Apoptosis, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Images
Image no. 1 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 1)
Image no. 2 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 2)
Image no. 3 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 3)
Image no. 4 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 4)
Image no. 5 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 5)
Image no. 6 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 6)
Image no. 7 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 7)
Image no. 8 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 8)
Image no. 9 for anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (ABIN1105269) anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 9)