Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody

Catalog No. ABIN1105519

Product Details

Target:

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Specificity: This antibody reacts to GRK2.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat and Monkey.

Purification: Ascites

Clone: 3F8

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Target Details

Target:

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

Alternative Name: beta-ARK-1 / ADRBK1 (ADRBK1 Antibody Abstract)

Synonyms: Adrbk-1, Bark-1, GRK2, betaARK1, BARK1, BETA-ARK1, GRK-2, Grk2, beta-adrenergic receptor kinase 1, G protein-coupled receptor kinase 2, Tsp_00497, grk2, Grk2, GRK2

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytesSynonyms: BARK, BARK1, Beta-adrenergic receptor kinase 1, G-protein coupled receptor kinase 2, GRK2

Molecular Weight: 80 kDa

Gene ID: 156

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling