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CD130/gp130 antibody

IL6ST Reactivity: Human FACS, Func Host: Mouse Monoclonal B-K5 unconjugated
Catalog No. ABIN1105845
  • Target See all CD130/gp130 (IL6ST) Antibodies
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Reactivity
    • 138
    • 66
    • 55
    • 20
    • 18
    • 18
    • 17
    • 4
    • 1
    • 1
    Human
    Host
    • 115
    • 25
    • 3
    • 2
    • 1
    Mouse
    Clonality
    • 117
    • 29
    Monoclonal
    Conjugate
    • 52
    • 15
    • 9
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD130/gp130 antibody is un-conjugated
    Application
    • 97
    • 39
    • 37
    • 30
    • 28
    • 26
    • 18
    • 13
    • 9
    • 9
    • 9
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func)
    Specificity
    Recognizes the soluble antigen. Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Ion Exchange Chromatography.
    Sterility
    0.22 μm filtered
    Immunogen
    Natural soluble gp130. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
    Clone
    B-K5
    Isotype
    IgG1
    Top Product
    Discover our top product IL6ST Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
    Preservative
    Without preservative
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Alternative Name
    CD130 / IL6ST (IL6ST Products)
    Synonyms
    CD130 antibody, CDW130 antibody, GP130 antibody, IL-6RB antibody, 5133400A03Rik antibody, AA389424 antibody, BB405851 antibody, D13Ertd699e antibody, gp130 antibody, Ac1055 antibody, Gp130 antibody, Il-6rb antibody, IL-6 antibody, interleukin 6 signal transducer antibody, IL6ST antibody, Il6st antibody, il6st antibody
    Background
    IL-6 activates intracellular signaling through binding a receptor consisting of an 80 kDa ligand-binding protein (IL-6R) and a second protein of 130 kDa. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6R is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-tocell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
    Gene ID
    3572
    NCBI Accession
    NP_002175
    UniProt
    P40189
    Pathways
    JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
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