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TLR2 antibody

TLR2 Reactivity: Mouse IP, IHC (fro), EIA Host: Mouse Monoclonal mTL2-7 unconjugated
Catalog No. ABIN7101942
  • Target See all TLR2 Antibodies
    TLR2 (Toll-Like Receptor 2 (TLR2))
    Reactivity
    • 16
    • 6
    • 1
    • 1
    • 1
    Mouse
    Host
    • 14
    • 7
    Mouse
    Clonality
    • 14
    • 7
    Monoclonal
    Conjugate
    • 16
    • 2
    • 2
    • 1
    This TLR2 antibody is un-conjugated
    Application
    • 11
    • 11
    • 8
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificity
    Monoclonal antibody mT2.7 reacts with mouse Toll-like receptor 2 (TLR2). The monoclonal antibody mT2.7 stained overexpressed, as well as endogenous cell surface- and intercellular TLR2. The antibody does not affect cell activation through TLR2.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse.
    Purification
    Purified
    Clone
    MTL2-7
    Isotype
    IgG2a
    Top Product
    Discover our top product TLR2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0,1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 0,1 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    TLR2 (Toll-Like Receptor 2 (TLR2))
    Alternative Name
    CD282 / TLR2 (TLR2 Products)
    Synonyms
    CD282 antibody, TIL4 antibody, Ly105 antibody, toll like receptor 2 antibody, toll-like receptor 2 antibody, TLR2 antibody, Tlr2 antibody, tlr2 antibody
    Background
    Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2.Synonyms: Toll-like receptor 2
    Gene ID
    9606
    UniProt
    O60603
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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