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IL12B antibody

IL12B Reactivity: Human, Sheep, Cow WB, FACS, EIA, Func, ELISpot Host: Mouse Monoclonal CC301 unconjugated
Catalog No. ABIN1107794
  • Target See all IL12B Antibodies
    IL12B (Interleukin 12 beta (IL12B))
    Reactivity
    • 63
    • 41
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Sheep, Cow
    Host
    • 80
    • 19
    • 3
    • 2
    Mouse
    Clonality
    • 83
    • 21
    Monoclonal
    Conjugate
    • 61
    • 9
    • 9
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL12B antibody is un-conjugated
    Application
    • 86
    • 58
    • 35
    • 16
    • 13
    • 13
    • 13
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Functional Studies (Func), ELISpot
    Specificity
    This antibody recognises the p40 subunit of Bovine Interleukin-12, and binds to both the free subunit and the intact heterodimer.
    Purification
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
    Endotoxin Level
    < 0.01 EU/μg
    Clone
    CC301
    Isotype
    IgG2a
    Top Product
    Discover our top product IL12B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, None, None
  • Target
    IL12B (Interleukin 12 beta (IL12B))
    Alternative Name
    Interleukin-12 beta / IL12B (IL12B Products)
    Synonyms
    CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, IL-12 p40 antibody, il12b antibody, il12p40.b antibody, zgc:152789 antibody, IL-12.p40 antibody, IL12p40 antibody, IL12B antibody, CLMF p40 antibody, interleukin 12B antibody, interleukin 12b antibody, interleukin 12Ba antibody, IL12B antibody, Il12b antibody, il12ba antibody
    Background
    Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2
    Gene ID
    281857
    Pathways
    JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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