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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3751-3968) antibody Primary Antibody

MLL Reactivity: Human EIA, IHC (p), WB Host: Mouse Monoclonal 10F8D7 unconjugated
Catalog No. ABIN1108254
$462.00
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0.1 mL
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  • Target
    Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL)
    Binding Specificity
    AA 3751-3968
    • 9
    • 7
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human
    • 38
    • 12
    • 9
    Host
    Mouse
    • 35
    • 3
    Clonality
    Monoclonal
    • 36
    • 2
    Conjugate
    Un-conjugated
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    • 20
    • 19
    • 19
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Specificity
    Recognizes Human MLL. Other species not tested.
    Purification
    Ascites
    Clone
    10F8D7
    Isotype
    IgG1
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
  • Target
    Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL)
    Alternative Name
    MLL / HRX (MLL Antibody Abstract)
    Synonyms
    ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS, 6430520K01, All1, Cxxc7, Mll, Mll1, mKIAA4050, lysine methyltransferase 2A, lysine (K)-specific methyltransferase 2A, KMT2A, Kmt2a
    Background
    Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN)functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.Synonyms: ALL-1, ALL1, CXXC-type zinc finger protein 7, CXXC7, HTRX, Histone-lysine N-methyltransferase HRX, KMT2A, Lysine N-methyltransferase 2A, TRX1, Trithorax-like protein, Zinc finger protein HRX
    Gene ID
    4297
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