Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3751-3968) antibody

Details for Product No. ABIN1108254
Antigen
Epitope
AA 3751-3968
10
8
7
7
4
2
2
2
2
1
1
1
1
Reactivity
Human
57
17
11
Host
Mouse
45
12
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
33
31
28
10
5
3
3
2
2
2
1
Options
Clone 10F8D7
Isotype IgG1
Specificity Recognizes Human MLL. Other species not tested.
Purification Ascites
Antigen
Alternative Name MLL / HRX (MLL Antibody Abstract)
Background Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN)functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.Synonyms: ALL-1, ALL1, CXXC-type zinc finger protein 7, CXXC7, HTRX, Histone-lysine N-methyltransferase HRX, KMT2A, Lysine N-methyltransferase 2A, TRX1, Trithorax-like protein, Zinc finger protein HRX
Gene ID 4297
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Image no. 1 for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3751-3968) antibody (ABIN1108254) anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3751-3968) antibody (Image 1)
Image no. 2 for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3751-3968) antibody (ABIN1108254) anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (AA 3751-3968) antibody (Image 2)