MTF1 antibody (C-Term)

Catalog No. ABIN1108308

Product Details anti-MTF1 Antibody

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTF1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QSSLVMGEQN LQWILNGATS SPQNQEQIQQ ASKVEKVFFT TAVPVASSPG

Cross-Reactivity (Details): Species reactivity (expected):Mouse (100 %), Rat (100 %), Dog (100 %), Bovine (100 %), Horse (100 %), Guinea Pig (92 %), Rabbit (92 %).
Species reactivity (tested):Human.

Purification: Purified on Protein A affinity column.

Immunogen: The immunogen for anti-MTF1 antibody: synthetic peptide directed towards the C terminal of human MTF1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the lyophised antibody at -20 °C for up to one year. Store reconstitued antibody undiluted for one month or in aliquots at -20 °C long term.

Expiry Date: 12 months

Target Details for MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Alternative Name: MTF1 (MTF1 Products)

Synonyms: MTF-1 antibody, MTF1 antibody, mtf1 antibody, MGC86485 antibody, Thyls antibody, ZRF antibody, metal regulatory transcription factor 1 antibody, metal-regulatory transcription factor 1 antibody, metal-regulatory transcription factor 1 L homeolog antibody, metal response element binding transcription factor 1 antibody, MTF1 antibody, mtf1 antibody, mtf1.L antibody, Mtf1 antibody

Background: The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein.Synonyms: MRE-binding transcription factor, Metal regulatory transcription factor 1, Transcription factor MTF-1

Molecular Weight: 81 kDa (753 amino acids)

Gene ID: 4520

NCBI Accession: NP_005946