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PSMC3 antibody (Middle Region)

PSMC3 Reactivity: Human, Mouse, Rat, Xenopus laevis, Dog, Zebrafish (Danio rerio), Cow, Chicken WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1108775
  • Target See all PSMC3 Antibodies
    PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
    Binding Specificity
    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 61
    • 41
    • 27
    • 20
    • 11
    • 9
    • 8
    • 8
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Xenopus laevis, Dog, Zebrafish (Danio rerio), Cow, Chicken
    Host
    • 54
    • 7
    Rabbit
    Clonality
    • 56
    • 5
    Polyclonal
    Conjugate
    • 36
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSMC3 antibody is un-conjugated
    Application
    • 48
    • 17
    • 15
    • 13
    • 13
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Sequence
    TKRFDSEKAG DREVQRTMLE LLNQLDGFQP NTQVKVIAAT NRVDILD
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Dog, Rat, Chicken, Bovine, Zebrafish, African clawed frogSpecies reactivity (tested):Human
    Purification
    Purified using Protein A affinity column.
    Immunogen
    The immunogen for anti-PSMC3 antibody: synthetic peptide directed towards the middle region of human PSMC3.
    Top Product
    Discover our top product PSMC3 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Reconstitution
    Add 100 μL of distilled water to a final concentration of 1 mg/mL.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
  • Target
    PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
    Alternative Name
    PSMC3 / TBP1 (PSMC3 Products)
    Synonyms
    TBP1 antibody, TBP-1 antibody, wu:fb39a02 antibody, zgc:86713 antibody, psmc3 antibody, MGC89608 antibody, PSMC3 antibody, NV15940 antibody, 23.m06430 antibody, DDBDRAFT_0186002 antibody, DDBDRAFT_0232967 antibody, DDB_0186002 antibody, DDB_0232967 antibody, psmc3-b antibody, tbp10 antibody, psmc3-a antibody, proteasome 26S subunit, ATPase 3 antibody, proteasome (prosome, macropain) 26S subunit, ATPase 3 antibody, 26S protease regulatory subunit 6A antibody, 26S protease regulatory subunit 6a antibody, 26S protease regulatory subunit 6A-B antibody, 26S protease regulatory subunit 6A, putative antibody, proteasome 26S subunit, ATPase 3 S homeolog antibody, nth-like DNA glycosylase 1 S homeolog antibody, PSMC3 antibody, Psmc3 antibody, HCAG_00069 antibody, GL50803_4365 antibody, EDI_316920 antibody, CpipJ_CPIJ006888 antibody, CpipJ_CPIJ006889 antibody, CpipJ_CPIJ010864 antibody, prs6a antibody, psmc3 antibody, LOC100115023 antibody, BBOV_IV004580 antibody, CGB_M2140W antibody, psmC3 antibody, LOC100637883 antibody, psmc3.S antibody, nthl1.S antibody
    Background
    PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.Synonyms: 26S protease regulatory subunit 6A, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, TBP-1, Tat-binding protein 1
    Gene ID
    5702
    NCBI Accession
    NP_002795
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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