SCD antibody

Catalog No. ABIN1108939

Product Details anti-SCD Antibody

Target: SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCD antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to SCD / SCD1.

Purification: Affinity Purified

Immunogen: Full length recombinant protein

Clone: CD-E10

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS, pH 7.4 with 0.05 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SCD

Target: SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD))

Alternative Name: SCD / SCD1 (SCD Products)

Synonyms: FADS5 antibody, MSTP008 antibody, SCD1 antibody, SCDOS antibody, AA589638 antibody, AI265570 antibody, Scd antibody, Scd-1 antibody, ab antibody, SCD antibody, fads5 antibody, scd1 antibody, scdos antibody, F27J15.17 antibody, F27J15_17 antibody, STOMATAL CYTOKINESIS-DEFECTIVE 1 antibody, cds2 antibody, desaturase antibody, stearoyl-CoA desaturase antibody, acyl-CoA desaturase antibody, Acyl-CoA desaturase antibody, stearoyl-Coenzyme A desaturase 1 antibody, stearoyl-CoA desaturase (delta-9-desaturase) antibody, stearoyl-CoA desaturase (delta-9-desaturase) S homeolog antibody, stomatal cytokinesis defective / SCD1 protein (SCD1) antibody, acyl-CoA desaturase-like antibody, SCD antibody, CIMG_08158 antibody, VIBHAR_RS23280 antibody, acod antibody, Scd1 antibody, Scd antibody, scd antibody, LOC100346561 antibody, scd.S antibody, SCD1 antibody, LOC100719661 antibody, LOC101835884 antibody, LOC109101093 antibody

Background: Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355aa, rat 358aa, ~37 KDa) is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. The SCD-1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD-1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders.Synonyms: Acyl-CoA desaturase, Delta(9)-desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase

Gene ID: 6319

NCBI Accession: NP_005054

UniProt: O00767

Pathways: Brown Fat Cell Differentiation