Cardiotrophin 1 antibody

Catalog No. ABIN1110877

Product Details anti-Cardiotrophin 1 Antibody

Target: Cardiotrophin 1 (CTF1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cardiotrophin 1 antibody is un-conjugated

Application: ELISA

Purpose: Mouse Anti-Human CT1

Characteristics: Cardiac Markers

Purification: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen.PurificationThe IgG fraction of tissue culture supernatant was purified by Protein A/G affinity chromatography.

Isotype: IgG

Application Details

Application Notes: ELISA

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: The antibody is supplied as lyophilized and purified antibody originally containing PBS without any preservatives. Protein amount is indicated on the vial. Reconstitute in de-ionized or distilled water to concentration of 1 mg/mL.

Buffer: PBS

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: -20°C

References for anti-Cardiotrophin 1 antibody (ABIN1110877)

Li, Ma, Wang, Zeng, Li, Kang, Hao: "Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients." in: OncoTargets and therapy, Vol. 9, pp. 139-48, (2016) (PubMed).

Target Details for Cardiotrophin 1

Target: Cardiotrophin 1 (CTF1)

Alternative Name: CT1 (CTF1 Products)

Synonyms: CTF1 antibody, ct1 antibody, ct-1 antibody, ctf2 antibody, CT-1 antibody, CT1 antibody, cardiotrophin 1 antibody, cardiotrophin-1 antibody, CTF1 antibody, ctf1 antibody, Ctf1 antibody, LOC100736818 antibody

Background:

Target Description: Cardiotrophin-1 (CT-1, Official gene name: CTF1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130/leukemia inhibitory factor receptor beta heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase in cardiac myocytes. It is also highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Pathways: JAK-STAT Signaling