Integrin Alpha2b antibody (Biotin)

Catalog No. ABIN1112135

Product Details anti-Integrin Alpha2b Antibody (Biotin)

Target: Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Characteristics: Monoclonal Mouse Anti-Human CD41 BIOTIN is recommended for use in flow cytometry for identification of Erythroblast.

Clone: HIP8

Isotype: IgG1

Application Details

Application Notes: It is recommended for use in flow cytometry. This reagent is effective for direct immunofluorescence staining of human tissue for flow cytometric analysis using 10 µl, 1/100, of the suggested working dilution to label 10^6 cells.

Comment:

BIOTIN (Sigma).

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The conjugate is provided in liquid form in buffer containing Antibody Stabilizer.

Storage: 4 °C

References for anti-Integrin Alpha2b antibody (Biotin) (ABIN1112135)

Menéndez, del Cañizo, Orfao: "Immunophenotypic characteristics of PB-mobilised CD34+ hematopoietic progenitor cells." in: Journal of biological regulators and homeostatic agents, Vol. 15, Issue 1, pp. 53-61, (2001) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 (CD41 Products)

Synonyms: AI172977 antibody, CD41 antibody, CD41B antibody, GpIIb antibody, alphaIIb antibody, BDPLT16 antibody, BDPLT2 antibody, GP2B antibody, GPIIb antibody, GT antibody, GTA antibody, HPA3 antibody, integrin alpha 2b antibody, integrin subunit alpha 2b antibody, Itga2b antibody, ITGA2B antibody

Background: This clone has been clustered to CD41 in the fourth international Workshop on Human White Cell differentiation Antigens. The antibody recognises the intact platelet gpIIb/IIIa complex, it does not bind to dissociated gpIIb or gpIIIa only to gpIIb in the intact complex. This is found on platelets, megakaryocytes and monocytes. Acute megakaryoblastic l leukaemia cells are positive for the gpIIb/IIIa antigen whereas common myeloid leukaemias are negative. CD41 is expressed on platelets and megakaryocytes. CD41 is the integrin aIIb subunit that is expressed as a heterodimer non-covalently associated with the integrin b3 subunit CD61. The association between CD41 and CD61 is calcium dependent.

Pathways: Integrin Complex