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BMI1 antibody
BMI1
Reactivity: Mouse
WB, IHC, IHC (p), ICC
Host: Mouse
Monoclonal
P9
unconjugated
Product Details anti-BMI1 Antibody
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Target
See all BMI1 Antibodies
BMI1
(BMI1 Polycomb Ring Finger Oncogene (BMI1))
Reactivity
All reactivities for BMI1 antibodies
Mouse
Host
All hosts for BMI1 antibodies
Mouse
Clonality
All clonalities for BMI1 antibodies
Monoclonal
Conjugate
All conjugates for BMI1 antibodies
This BMI1 antibody is un-conjugated
Application
All applications for BMI1 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
Immunogen
Recombinant Polycomb complex protein BMI-1 protein.
Clone
P9
Isotype
IgG2a
Top Product
Discover our top product BMI1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB (1:1000-5000), IHC-P (1:200), ICC (1:500). Other applications have not been tested. The optimal dilutions should be determined by end user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
Preservative
Sodium azide, Thimerosal (Merthiolate)
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.
Expiry Date
12 months
Target Details for BMI1
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Target
BMI1
(BMI1 Polycomb Ring Finger Oncogene (BMI1))
Alternative Name
Polycomb complex protein BMI-1 (BMI1 Products )
Synonyms
FLVI2/BMI1 antibody, PCGF4 antibody, RNF51 antibody, AW546694 antibody, Bmi-1 antibody, Pcgf4 antibody, bmi1 antibody, pcgf4 antibody, psc1 antibody, wu:fb17g03 antibody, wu:fd18f06 antibody, BMI-1 antibody, pcgf4b antibody, bmi-1 antibody, bmi1-a antibody, bmi1-b antibody, bmi1b antibody, rnf51 antibody, xbmi-1 antibody, BMI1 proto-oncogene, polycomb ring finger antibody, BMI1 polycomb ring finger oncogene antibody, Bmi1 polycomb ring finger oncogene antibody, bmi1 polycomb ring finger oncogene 1a antibody, bmi1 polycomb ring finger oncogene 1b antibody, BMI1 proto-oncogene, polycomb ring finger L homeolog antibody, BMI1 antibody, LOC100230513 antibody, Bmi1 antibody, bmi1a antibody, bmi1b antibody, bmi1.L antibody
Background
BMI1 has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. It is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. BMI1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. BMI1 is also thought to inhibit ageing in neurons through the suppression of p53.
Pathways
Cell Division Cycle , Autophagy
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