BMPR2 antibody

Catalog No. ABIN1112849

Product Details anti-BMPR2 Antibody

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: affinity purified

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of BMPR2.

Isotype: IgG

Application Details

Application Notes: Western Blot (1:100-500), Immunohistochemistry, IHC (1:100-500), Immunocytochemistry, ICC (1:100-500). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for BMPR2

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Alternative Name: Bone morphogenetic protein receptor type II, BMPR2 (BMPR2 Products)

Synonyms: BMPR-II antibody, BMPR3 antibody, BMR2 antibody, BRK-3 antibody, PPH1 antibody, T-ALK antibody, 2610024H22Rik antibody, AL117858 antibody, AW546137 antibody, BB189135 antibody, BMP-2 antibody, BMPR-2 antibody, BMPRII antibody, Gm20272 antibody, Bmpr-II antibody, bmprii antibody, bone morphogenetic protein receptor type 2 antibody, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antibody, bone morphogenetic protein receptor, type II (serine/threonine kinase) antibody, BMPR2 antibody, bmpr2b antibody, Bmpr2 antibody

Background: Bone morphogenetic protein receptor type II, BMPR2 is a serine/threonine receptor kinase. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Unlike the TGF beta type II receptor, which has a high affinity for TGF- beta1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor. 1 The low affinity for ligands suggests that BMPR2 may differ in the from other type II TGF beta receptors in that the ligand may bind the type I receptor first. 2

Pathways: Growth Factor Binding