CRP antibody

Catalog No. ABIN114519

The Mouse Monoclonal anti-CRP antibody (Clone 67A1) (ABIN114519) specifically detects CRP in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for CRP antibody (ABIN114519)

Target: CRP (C-Reactive Protein (CRP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 67A1

Product Details anti-CRP Antibody

Specificity: This antibody reacts to C Reactive Protein.

Purification: Protein G affinity purified

Immunogen: Purified CRP from human pleural fluid

Isotype: IgG1

Application Details

Application Notes: ELISA. Immunoblot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with double distillated water is recommended and to adjust the final concentration to 1.00 mg/mL

Concentration: 1.00 mg/mL

Buffer: 0.01 M PBS, pH 7.2

Handling Advice: This product is photosensitive and should be protected from light

Storage: 4 °C

Storage Comment: Store the antibody at 2 - 8 °C. DO NOT FREEZE!

Target Details for CRP

Target: CRP (C-Reactive Protein (CRP))

Background: C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.Synonyms: C Reactive Protein, PTX1, Pentraxin-related

Gene ID: 1401

NCBI Accession: NP_000558

UniProt: P02741

Pathways: Carbohydrate Homeostasis