TRIB3 antibody (AA 112-125)

Catalog No. ABIN1169021

Product Details anti-TRIB3 Antibody

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Binding Specificity: AA 112-125

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: Recognizes human TRB-3. Detects a band of ~28 kDa by Western blot (predicted 39 kDa).

Cross-Reactivity: Human

Sterility: 0.2 μm filtered

Immunogen: Synthetic peptide corresponding to aa 112-125 (A112RLPPHKHVARPTE125) of human TRB-3.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for TRIB3

Target: TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))

Alternative Name: TRB-3 (TRIB3 Products)

Synonyms: zgc:76966 antibody, TRIB3 antibody, C20orf97 antibody, NIPK antibody, SINK antibody, SKIP3 antibody, TRB3 antibody, Ifld2 antibody, Nipk antibody, TRB-3 antibody, Trb3 antibody, tribbles pseudokinase 3 antibody, trib3 antibody, TRIB3 antibody, Trib3 antibody

Background: Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPARgamma, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. It interacts also with the NF-kappaB transactivator p65 RELA. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells.

UniProt: Q96RU7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha