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LAG3 antibody (N-Term)
LAG3
Reactivity: Human
WB, IHC, IP, FACS, ICC, Func
Host: Mouse
Monoclonal
17B4
unconjugated
Product Details anti-LAG3 Antibody
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Target
See all LAG3 Antibodies
LAG3
(Lymphocyte-Activation Gene 3 (LAG3))
Binding Specificity
All epitopes for LAG3 antibodies
N-Term
Reactivity
All reactivities for LAG3 antibodies
Human
Host
All hosts for LAG3 antibodies
Mouse
Clonality
All clonalities for LAG3 antibodies
Monoclonal
Conjugate
All conjugates for LAG3 antibodies
This LAG3 antibody is un-conjugated
Application
All applications for LAG3 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Functional Studies (Func)
Specificity
Recognizes human LAG-3.
Cross-Reactivity
Human
Purity
>95 % (SDS-PAGE)
Endotoxin Level
<0.001EU/μg purified protein or <1EU/mg purified protein (LAL test, Lonza).
Immunogen
Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.
Clone
17B4
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
In PBS.
Preservative
Without preservative
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date
12 months
Target Details for LAG3
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Target
LAG3
(Lymphocyte-Activation Gene 3 (LAG3))
Alternative Name
LAG-3 (LAG3 Products )
Synonyms
CD223 antibody, LAG-3 antibody, Ly66 antibody, lymphocyte activating 3 antibody, lymphocyte-activation gene 3 antibody, LAG3 antibody, Lag3 antibody
Background
Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
UniProt
P18627
Pathways
Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Cancer Immune Checkpoints
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