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IL1A antibody

IL1A Reactivity: Mouse WB, ELISA Host: Mouse Monoclonal Bamboo-1 unconjugated
Catalog No. ABIN1169127
  • Target See all IL1A Antibodies
    IL1A (Interleukin 1 alpha (IL1A))
    Reactivity
    • 108
    • 48
    • 40
    • 12
    • 10
    • 9
    • 9
    • 8
    • 8
    • 5
    • 5
    • 2
    • 2
    Mouse
    Host
    • 143
    • 37
    • 10
    • 5
    • 3
    • 2
    • 1
    Mouse
    Clonality
    • 158
    • 41
    Monoclonal
    Conjugate
    • 103
    • 46
    • 18
    • 11
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL1A antibody is un-conjugated
    Application
    • 146
    • 97
    • 65
    • 27
    • 26
    • 24
    • 18
    • 12
    • 10
    • 9
    • 9
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    Recognizes mouse IL-1alpha.
    Cross-Reactivity
    Mouse (Murine)
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Purity
    >95 % (SDS-PAGE)
    Immunogen
    Recombinant mouse mature IL-1alpha.
    Clone
    Bamboo-1
    Isotype
    IgG
    Top Product
    Discover our top product IL1A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Target
    IL1A (Interleukin 1 alpha (IL1A))
    Alternative Name
    IL-1alpha (IL1A Products)
    Synonyms
    IL-1A antibody, IL1 antibody, IL1-ALPHA antibody, IL1F1 antibody, IL-6 antibody, Il-1a antibody, IL-1 alpha antibody, IL-1alpha antibody, L1A antibody, interleukin 1 alpha antibody, interleukin 6 antibody, IL1A antibody, IL6 antibody, Il1a antibody
    Background
    The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
    UniProt
    P01582
    Pathways
    NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
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