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IL1RL1 antibody

IL1RL1 Reactivity: Human WB, ELISA, FACS Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1169349
  • Target See all IL1RL1 Antibodies
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    Reactivity
    • 59
    • 28
    • 21
    • 6
    • 4
    • 4
    • 1
    Human
    Host
    • 48
    • 11
    • 1
    • 1
    Rabbit
    Clonality
    • 47
    • 14
    Polyclonal
    Conjugate
    • 31
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL1RL1 antibody is un-conjugated
    Application
    • 30
    • 29
    • 16
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    Specificity
    Recognizes soluble human ST2. Detects a band of ~50 kDa by Western blot and the endogenous ST2 by Flow Cytometry.
    Cross-Reactivity
    Human
    Sterility
    0.2 μm filtered
    Immunogen
    Recombinant human soluble ST2.
    Top Product
    Discover our top product IL1RL1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Target
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    Alternative Name
    ST2 (IL1RL1 Products)
    Synonyms
    DER4 antibody, Fit-1 antibody, Ly84 antibody, ST2L antibody, St2 antibody, St2-rs1 antibody, T1 antibody, T1/ST2 antibody, FIT-1 antibody, IL33R antibody, ST2 antibody, ST2V antibody, FIT1 antibody, interleukin 1 receptor-like 1 antibody, interleukin 1 receptor like 1 antibody, Il1rl1 antibody, IL1RL1 antibody
    Background
    ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
    UniProt
    Q01638
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