FNDC5 antibody

Catalog No. ABIN1169430

Product Details anti-FNDC5 Antibody

Target: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNDC5 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2].

Cross-Reactivity: Human, Monkey, Mouse (Murine), Rat (Rattus)

Immunogen: Recombinant irisin.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-FNDC5 antibody (ABIN1169430)

Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: "Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway." in: Cell metabolism, Vol. 18, Issue 5, pp. 649-59, (2013) (PubMed).

Target Details for FNDC5

Target: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Alternative Name: Irisin (FNDC5 Products)

Synonyms: FRCP2 antibody, irisin antibody, 1500001L03Rik antibody, AI836596 antibody, C87088 antibody, PeP antibody, Pxp antibody, fndc5 antibody, si:dkey-264p5.1 antibody, zgc:158684 antibody, fibronectin type III domain containing 5 antibody, fibronectin type III domain containing 5b antibody, FNDC5 antibody, Fndc5 antibody, fndc5b antibody

Background: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

UniProt: Q8NAU1

Pathways: Hormone Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation