FCGR1A antibody

Catalog No. ABIN1176933

Product Details anti-FCGR1A Antibody

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCGR1A antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen: Human rheumatoid synovial fluid cells and fibronectin-purified monocytes

Clone: 10-1

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

References for anti-FCGR1A antibody (ABIN1176933)

van Vugt, Heijnen, Capel, Park, Ra, Saito, Verbeek, van de Winkel: "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo." in: Blood, Vol. 87, Issue 9, pp. 3593-9, (1996) (PubMed).

Dougherty, Selvendran, Murdoch, Palmer, Hogg: "The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1." in: European journal of immunology, Vol. 17, Issue 10, pp. 1453-9, (1987) (PubMed).

Target Details for FCGR1A

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Alternative Name: CD64 (FCGR1A Products)

Synonyms: CD64 antibody, CD64A antibody, FCRI antibody, IGFR1 antibody, FcgammaRI antibody, Fcgr1 antibody, Fcgr1b antibody, AI323638 antibody, AV092959 antibody, IGGHAFC antibody, FCGR1A antibody, Fc fragment of IgG receptor Ia antibody, Fc receptor, IgG, high affinity I antibody, FCGR1A antibody, Fcgr1a antibody, Fcgr1 antibody

Background: The 10.1 monoclonal antibody specifically binds to CD64, a 75 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcgammaRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRgamma homodimer to form the functional high affinity FcgammaRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation.
Synonyms: FCGR1, FcRI, Fc-gamma RI, IgG Fc Receptor I, High affinity IgG FcR1

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process