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PDGFRA antibody
PDGFRA
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
APA5
unconjugated
Product Details anti-PDGFRA Antibody
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Target
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PDGFRA
(Platelet Derived Growth Factor Receptor alpha (PDGFRA))
Reactivity
All reactivities for PDGFRA antibodies
Mouse
Host
All hosts for PDGFRA antibodies
Rat
Clonality
All clonalities for PDGFRA antibodies
Monoclonal
Conjugate
All conjugates for PDGFRA antibodies
This PDGFRA antibody is un-conjugated
Application
All applications for PDGFRA antibodies
Flow Cytometry (FACS)
Brand
BD Pharmingen™
Purification
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterility
0.2 μm filtered
Endotoxin Level
Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen
Mouse PDGF Receptor alpha chain
Clone
APA5
Isotype
IgG2a kappa
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Discover our top product PDGFRA Primary Antibody
Alternatives
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Application Details
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Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Preservative
Azide free
Storage
4 °C
Storage Comment
Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
References for anti-PDGFRA antibody (ABIN1176995)
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Fruttiger, Calver, Krüger, Mudhar, Michalovich, Takakura, Nishikawa, Richardson : "PDGF mediates a neuron-astrocyte interaction in the developing retina. " in: Neuron , Vol. 17 , Issue 6 , pp. 1117-31 , (1997 ) (PubMed ).
Takakura, Yoshida, Kunisada, Nishikawa, Nishikawa : "Involvement of platelet-derived growth factor receptor-alpha in hair canal formation. " in: The Journal of investigative dermatology , Vol. 107 , Issue 5 , pp. 770-7 , (1996 ) (PubMed ).
Heldin : "Structural and functional studies on platelet-derived growth factor. " in: The EMBO journal , Vol. 11 , Issue 12 , pp. 4251-9 , (1992 ) (PubMed ).
Target Details for PDGFRA
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Target
PDGFRA
(Platelet Derived Growth Factor Receptor alpha (PDGFRA))
Alternative Name
CD140A (PDGFRA Products )
Synonyms
AI115593 antibody, CD140a antibody, Pdgfr-2 antibody, APDGFR antibody, PDGFACE antibody, CD140A antibody, PDGFR-2 antibody, PDGFR2 antibody, RHEPDGFRA antibody, PDGFR antibody, PDGFR-A antibody, platelet derived growth factor receptor alpha antibody, platelet derived growth factor receptor, alpha polypeptide antibody, platelet-derived growth factor receptor, alpha polypeptide L homeolog antibody, platelet-derived growth factor receptor, alpha polypeptide antibody, PDGFRA antibody, Pdgfra antibody, pdgfra.L antibody
Background
The APA5 antibody monoclonal antibody specifically binds to the Platelet-Derived Growth Factor (PDGF) Receptor alpha chain (CD140a, PDGFR-a), a receptor tyrosine kinase that is widely expressed on cells of mesenchymal origin in the embryo and adult and on several other cell types during embryonic development, but not on hematopoietic cells. PDGFR-a binds to PDGF A and B chains, in contrast to PDGFR-b, that binds only to the PDGF B chain. Biologically active PDGF is a disulphide-linked dimer, forming the AA, AB, and BB isoforms. Ligand binding to the PDGF Receptor induces the formation of receptor dimers (aa, ab, or bb), autophosphorylation, and internalization. The APA5 antibody has been demonstrated to block binding of PDGF-AA to PDGFR-a-expressing cells in vitro and to block some PDGF-mediated developmental events in vivo. Synonyms: Pdgfra, Pdgfr2, PDGF-R alpha, Platelet derived growth factor receptor alpha
Pathways
RTK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Platelet-derived growth Factor Receptor Signaling
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