IL2 Receptor beta antibody (Interleukin 2 Receptor, beta)

Details for Product anti-IL2RB Antibody No. ABIN1177313, Supplier: Log in to see
Antigen
  • IL2RB
  • il-2rb
  • CD122
  • IL15RB
  • P70-75
  • IL2RBC
  • IL-15Rbeta
  • IL15Rbeta
  • Il-2/15Rbeta
  • Il-2Rbeta
  • p70
  • interleukin 2 receptor subunit beta
  • interleukin-2 receptor subunit beta
  • interleukin 2 receptor, beta
  • interleukin 2 receptor, beta chain
  • IL2RB
  • LOC510185
  • il2rb
  • Il2rb
Alternatives
anti-Human IL2 Receptor beta antibody for Flow Cytometry
Reactivity
Mouse (Murine)
214
180
82
29
10
1
1
Host
Rat
142
123
69
Clonality (Clone)
Monoclonal ()
Conjugate
This IL2 Receptor beta antibody is un-conjugated
30
28
21
14
6
5
4
4
4
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP)
183
128
66
62
42
26
14
14
12
10
8
4
4
2
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Brand BD Pharmingen™
Immunogen Flow cytometry, Immunoprecipitation
Clone TM-beta 1
Isotype IgG2b, kappa
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Plasmids, Primers & others Plasmids, Primers & others IL2 Receptor beta products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD122 (IL2RB Antibody Abstract)
Background The TM-beta1 antibody reacts with the 90-100-kDa beta chain shared by the IL-2 and IL-15 receptors (IL-2Rbeta, CD122). In the periphery, CD122 is expressed on CD8+ T lymphocytes, NK cells, NK-T cells, dendritic epidermal T cells, subsets of intraepithelial lymphocytes, and macrophages. Small subsets of fetal and adult thymocytes constitutively express CD122. CD122+ cells in the bone marrow include committed NK-cell progenitors. IL-2Rbeta expression is upregulated by IL-2. CD122 is a transmembrane glycoprotein of the hematopoietin receptor superfamily which can combine with CD132 (gammac) alone or CD132 plus CD25 (IL-2Ralpha) to form intermediate or high-affinity IL-2 receptor complexes, respectively. The beta chain of these complexes, CD122, is involved in signal transduction and immunoregulation. The TM-beta1 antibody blocks high affinity binding of IL-2 or IL-15 to IL-2Rbeta.
Synonyms: IL-2 and IL-15 Receptor beta Chain
Pathways JAK-STAT Signaling, Growth Factor Binding
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Preservative Azide free
Storage 4 °C
Storage Comment Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Product cited in: Rosmaraki, Douagi, Roth, Colucci, Cumano, Di Santo: "Identification of committed NK cell progenitors in adult murine bone marrow." in: European journal of immunology, Vol. 31, Issue 6, pp. 1900-9, 2001 (PubMed).

Ku, Murakami, Sakamoto, Kappler, Marrack: "Control of homeostasis of CD8+ memory T cells by opposing cytokines." in: Science (New York, N.Y.), Vol. 288, Issue 5466, pp. 675-8, 2000 (PubMed).

Cho, Wang, Sugawa, Eisen, Chen: "Functional differences between memory and naive CD8 T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 2976-81, 1999 (PubMed).

Zhang, Sun, Hwang, Tough, Sprent: "Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15." in: Immunity, Vol. 8, Issue 5, pp. 591-9, 1998 (PubMed).

Alleva, Kaser, Monroy, Fenton, Beller: "IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 6, pp. 2941-51, 1997 (PubMed).

Guy-Grand, Cuénod-Jabri, Malassis-Seris, Selz, Vassalli: "Complexity of the mouse gut T cell immune system: identification of two distinct natural killer T cell intraepithelial lineages." in: European journal of immunology, Vol. 26, Issue 9, pp. 2248-56, 1996 (PubMed).

Bendelac: "Mouse NK1+ T cells." in: Current opinion in immunology, Vol. 7, Issue 3, pp. 367-74, 1995 (PubMed).

Malek, Furse, Fleming, Fadell, He: "Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 15, Issue 5, pp. 447-54, 1995 (PubMed).

Suzuki, Kündig, Furlonger, Wakeham, Timms, Matsuyama, Schmits, Simard, Ohashi, Griesser: "Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta." in: Science (New York, N.Y.), Vol. 268, Issue 5216, pp. 1472-6, 1995 (PubMed).

Hanke, Mitnacht, Boyd, Hünig: "Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus." in: The Journal of experimental medicine, Vol. 180, Issue 5, pp. 1629-36, 1994 (PubMed).

Kondo, Ohashi, Tada, Nakamura, Sugamura: "Expression of the mouse interleukin-2 receptor gamma chain in various cell populations of the thymus and spleen." in: European journal of immunology, Vol. 24, Issue 9, pp. 2026-30, 1994 (PubMed).

Giri, Ahdieh, Eisenman, Shanebeck, Grabstein, Kumaki, Namen, Park, Cosman, Anderson: "Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15." in: The EMBO journal, Vol. 13, Issue 12, pp. 2822-30, 1994 (PubMed).

Ohno, Ono, Hirayama, Shimada, Saito: "Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia." in: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 365-9, 1994 (PubMed).

Taniguchi, Minami: "The IL-2/IL-2 receptor system: a current overview." in: Cell, Vol. 73, Issue 1, pp. 5-8, 1993 (PubMed).

Nakanishi, Hirose, Yoshimoto, Ishizashi, Hiroishi, Tanaka, Kono, Miyasaka, Taniguchi, Higashino: "Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 8, pp. 3551-5, 1992 (PubMed).

Takeuchi, Tanaka, Hamamura, Sugimoto, Miyasaka, Yagita, Okumura: "Expression and role of interleukin-2 receptor beta chain on CD4-CD8- T cell receptor alpha beta+ cells [corrected]." in: European journal of immunology, Vol. 22, Issue 11, pp. 2929-35, 1992 (PubMed).

Tanaka, Takeuchi, Shiohara, Kitamura, Nagasaka, Hamamura, Yagita, Miyasaka: "In utero treatment with monoclonal antibody to IL-2 receptor beta-chain completely abrogates development of Thy-1+ dendritic epidermal cells." in: International immunology, Vol. 4, Issue 4, pp. 487-91, 1992 (PubMed).

Tanaka, Tsudo, Karasuyama, Kitamura, Kono, Hatakeyama, Taniguchi, Miyasaka: "A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 7, pp. 2222-8, 1991 (PubMed).

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