HTR1F antibody

Catalog No. ABIN121982

Product Details anti-HTR1F Antibody

Target: HTR1F (5-Hydroxytryptamine (serotonin) Receptor 1F (HTR1F))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTR1F antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody reacts to Serotonin Receptor 1F (Family: GPCR, Subfamily: Serotonin).

Purification: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemsiry on paraffin embedded sections: 5-8 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-80 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for HTR1F

Target: HTR1F (5-Hydroxytryptamine (serotonin) Receptor 1F (HTR1F))

Alternative Name: Serotonin Receptor 1F (HTR1F) (HTR1F Products)

Synonyms: 5-HT-1F antibody, 5-HT1F antibody, 5HT6 antibody, HTR1EL antibody, MR77 antibody, Htr1eb antibody, 5htr1e antibody, 5htr1f antibody, 5-hydroxytryptamine receptor 1F antibody, 5-hydroxytryptamine (serotonin) receptor 1F antibody, uncharacterized LOC100406194 antibody, HTR1F antibody, Htr1f antibody, LOC100406194 antibody

Background: 5-HT1F, a Serotonin Receptor, is negatively coupled to adenylate cyclase. Selective 5-HT1F agonists may prove therapeutic in the treatment of migraine headache, lacking the side effects associated with the agonists of the 5-HT1B and 5-HT1D receptors. Expression of the 5-HT1F receptor has been reported in various brain structures, including cortex, hippocampus, trigeminal ganglia, and cerebral blood vessels. Expression in peripheral tissues is limited to uterus, mesentery, and artery. No expression has been detected in heart, kidney, liver, pancreas, or spleen.Synonyms: 5-HT-1F, 5-hydroxytryptamine receptor 1F, HTR1EL

Gene ID: 3355

UniProt: P30939

Pathways: JAK-STAT Signaling