NR2E3 antibody

Catalog No. ABIN122365

Product Details anti-NR2E3 Antibody

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2E3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with Photoreceptor-Specific Nuclear Receptor (PNR/NR2E3) (family: NHR, subfamily: NR2 Hepatocyte NF4-like). BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 7 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.01 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-80 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for NR2E3

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Alternative Name: NR2E3 (NR2E3 Products)

Synonyms: ESCS antibody, PNR antibody, RNR antibody, RP37 antibody, rd7 antibody, LOC100228348 antibody, A930035N01Rik antibody, wu:fj55b07 antibody, zgc:103631 antibody, nuclear receptor subfamily 2 group E member 3 antibody, nuclear receptor subfamily 2, group E, member 3 antibody, NR2E3 antibody, Nr2e3 antibody, nr2e3 antibody

Background: Photoreceptor-specific nuclear receptor (PNR), a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in PNR results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in PNR has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. PNR is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.Synonyms: Nuclear receptor subfamily 2 group E member 3, PNR, Photoreceptor-specific nuclear receptor, RNR, Retina-specific nuclear receptor

Gene ID: 10002

UniProt: Q9Y5X4

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway