PRKG1 antibody (N-Term)
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- Target See all PRKG1 Antibodies
- PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKG1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- The antibody recognizes 75 kDa and 85 kDa PKG, corresponding to the Molecular Mass of twho PKG isoforms.
- Purification
- Immunoaffinity Chromatography
- Immunogen
- Synthetic peptide near the N-terminus of Human PKG.
- Top Product
- Discover our top product PRKG1 Primary Antibody
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- Application Notes
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Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 4-8 μg/mL. Immunohistochemistry: 4-8 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS, 0.01 % Thimerosal, 30 % Glycerol, 0.5 % BSA
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C/-80 °C
- Storage Comment
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- Target
- PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))
- Alternative Name
- CGK1 (PRKG1 Products)
- Synonyms
- prkg1 antibody, zgc:63955 antibody, Pkgi antibody, cGk1 antibody, 1 antibody, PKG antibody, PRKG1B antibody, PRKGR1B antibody, cGK antibody, cGK 1 antibody, cGK1 antibody, cGKI antibody, cGKI-BETA antibody, cGKI-alpha antibody, CGKI antibody, cGKI-beta antibody, AW125416 antibody, Gm19690 antibody, Prkg1b antibody, Prkgr1b antibody, Prkg1beta antibody, protein kinase, cGMP-dependent, type Ia antibody, protein kinase, cGMP-dependent, type I antibody, protein kinase, cGMP-dependent, type 1 antibody, prkg1a antibody, PRKG1 antibody, prkg1 antibody, Prkg1 antibody
- Background
- PKGs are cyclic GMP-dependent protein kinases (also designed cGKs) that are classified into two types, PKGI and PKGII. Studies have shown that cGKs and cyclic AMP-dependent kinases (cAKs) are highly homologous protein kinase families with similar substrate specificities. Phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility and platelet aggregation. However, recent studies using mice deficient in PKGs have shown that cGMP kinases regulate very specifically distinct pathways which are separate from those used by cyclic AMP kinases.Synonyms: CKG1A, CKG1B, PGK, PKG, PRKG1, PRKGR1A, PRKGR1B, cGKI-alpha, cGMP-dependent protein kinase 1
- Gene ID
- 5592
- NCBI Accession
- NP_001091982
- UniProt
- Q13976
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