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TCR alpha/beta antibody (Biotin)

TCR alpha/beta Reactivity: Human FACS Host: Mouse Monoclonal IP26 Biotin
Catalog No. ABIN1302746
  • Target See all TCR alpha/beta products
    TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))
    Reactivity
    • 18
    • 17
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
    Human
    Host
    • 31
    • 16
    Mouse
    Clonality
    • 47
    Monoclonal
    Conjugate
    • 15
    • 11
    • 9
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    This TCR alpha/beta antibody is conjugated to Biotin
    Application
    • 43
    • 26
    • 24
    • 22
    • 13
    • 8
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody IP26 recognizes a monomorphic extracellular determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
    Clone
    IP26
    Isotype
    IgG1
  • Application Notes
    Flow cytometry: Recommended dilution: 2-3 μg/mL, positive control: human peripheral blood T cells.
    Comment

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Avoid prolonged exposure to light.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: "NKp80 defines and stimulates a reactive subset of CD8 T cells." in: Blood, Vol. 113, Issue 2, pp. 358-69, (2009) (PubMed).

    Ortonne, Huet, Gaudez, Marie-Cardine, Schiavon, Bagot, Musette, Bensussan: "Significance of circulating T-cell clones in Sezary syndrome." in: Blood, Vol. 107, Issue 10, pp. 4030-8, (2006) (PubMed).

    Huet, Bagot, Loyaux, Capdevielle, Conraux, Ferrara, Bensussan, Marie-Cardine: "SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 652-9, (2005) (PubMed).

  • Target
    TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))
    Alternative Name
    TCR alpha/beta (TCR alpha/beta Products)
    Background
    The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.,TCRA/B
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