CD45RC antibody

Catalog No. ABIN133289

Product Details anti-CD45RC Antibody

Target: CD45RC

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD45RC antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Rat CD45RC

Purification: Purified

Immunogen: Phytohaemagglutinin-activated rat lymph node cells . FUSION PARTNER: P3-NSI-1-Ag4 (NS1/1) . IMMUNOCYTE DONOR: BALB/c Spleen

Clone: OX-22

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/ml

Storage: 4 °C

Target Details for CD45RC

Target: CD45RC

Alternative Name: CD45RC (CD45RC Products)

Synonyms: CD45 antibody, L-CA antibody, Lca antibody, RT7 antibody, T200 antibody, protein tyrosine phosphatase, receptor type, C antibody, Ptprc antibody

Background: Rat Leukocyte Common Antigen has been shown to exist in different forms on different lymphoid cell types. Rat L-CA on thymocytes gives one main band at 180 kDa, T cells show 4 bands at 180, 190, 200 and 220 kDa and B cells one broad band at 240 kDa. T helper and T cytotoxic cell subsets show the same 4 bands with some differences in the proportions of each. ABIN133289reacts with the high molecular weight form of the leukocyte common antigen (2) which includes the 240 kDa form on B cells as well as a subfraction of the 190, 200 and 220 kDa forms, but not with the 180 kDa form of T cells or thymocytes. (5) Thus, ABIN133289reacts with B cells, cytotoxic T cells and helper cells for T cell responses but not with thymocytes or helper T cells for in vivo antibody responses. (5) Consequently, this antibody can be used to identify B cells, all CD8+ve T cells, 75% CD4+ve T cells and 50% bone marrow cells. This, antibody also divides rat CD4+ve T cells into two phenotypically distinct populations differing in their helper activities (6,7).