CD130/gp130 antibody

Catalog No. ABIN1383681

Product Details anti-CD130/gp130 Antibody

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD130/gp130 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificity: Recognises Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-K5

Isotype: IgG1 kappa

Biological Activity Comment: Inhibits CNTF activity. Inhibits OSM binding to gp130

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-CD130/gp130 antibody (ABIN1383681)

Durda, Dunn, Rose, Butera, Benson, Pandolfi, Kurnick: "Induction of \" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression." in: Molecular cancer research : MCR, Vol. 1, Issue 6, pp. 411-9, (2003) (PubMed).

Auguste, Guillet, Fourcin, Olivier, Veziers, Pouplard-Barthelaix, Gascan: "Signaling of type II oncostatin M receptor." in: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15760-4, (1997) (PubMed).

Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." in: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, (1996) (PubMed).

Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, (1996) (PubMed).

Baumann, Morella, White, Dembski, Bailon, Kim, Lai, Tartaglia: "The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8374-8, (1996) (PubMed).

Target Details for CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Alternative Name: CD130 (IL6ST Products)

Synonyms: CD130 antibody, CDW130 antibody, GP130 antibody, IL-6RB antibody, 5133400A03Rik antibody, AA389424 antibody, BB405851 antibody, D13Ertd699e antibody, gp130 antibody, Ac1055 antibody, Gp130 antibody, Il-6rb antibody, IL-6 antibody, interleukin 6 signal transducer antibody, IL6ST antibody, Il6st antibody, il6st antibody

Background: Gp130

Molecular Weight: 130-140 kDa

Pathways: JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints