CD2 antibody

Catalog No. ABIN1383690

Product Details anti-CD2 Antibody

Target: CD2

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Functional Studies (Func)

Specificity: Recognises the Lymphocyte Function associated Antigen-2 (LFA-2), a 50 kDa protein

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Human thymocytes,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-E2

Isotype: IgG2b, kappa

Biological Activity Comment: Inhibits mixed lymphocyte culture

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-CD2 antibody (ABIN1383690)

Dupuis-Girod, Cancrini, Le Deist, Palma, Bodemer, Puel, Livadiotti, Picard, Bossuyt, Rossi, Fischer, Casanova: "Successful allogeneic hemopoietic stem cell transplantation in a child who had anhidrotic ectodermal dysplasia with immunodeficiency." in: Pediatrics, Vol. 118, Issue 1, pp. e205-11, (2006) (PubMed).

Tiberghien, Ferrand, Lioure, Milpied, Angonin, Deconinck, Certoux, Robinet, Saas, Petracca, Juttner, Reynolds, Longo, Hervé, Cahn: "Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft." in: Blood, Vol. 97, Issue 1, pp. 63-72, (2001) (PubMed).

Przepiorka, Phillips, Ratanatharathorn, Cottler-Fox, Sehn, Antin, LeBherz, Awwad, Hope, McClain: "A phase II study of BTI-322, a monoclonal anti-CD2 antibody, for treatment of steroid-resistant acute graft-versus-host disease." in: Blood, Vol. 92, Issue 11, pp. 4066-71, (1999) (PubMed).

Jabado, de Graeff-Meeder, Cavazzana-Calvo, Haddad, Le Deist, Benkerrou, Dufourcq, Caillat, Blanche, Fischer: "Treatment of familial hemophagocytic lymphohistiocytosis with bone marrow transplantation from HLA genetically nonidentical donors." in: Blood, Vol. 90, Issue 12, pp. 4743-8, (1997) (PubMed).

Cavazzana-Calvo, Bordigoni, Michel, Esperou, Souillet, Leblanc, Stephan, Vannier, Mechinaud, Reiffers, Vilmer, Landman-Parker, Benkerrou, Baruchel, Pico, Bernaudin, Bergeron, Plouvier, Thomas, Wijdenes, Lacour, Blanche, Fischer: "A phase II trial of partially incompatible bone marrow transplantation for high-risk acute lymphoblastic leukaemia in children: prevention of graft rejection with anti-LFA-1 and anti-CD2 antibodies. Société Française de Greffe de Moelle Osseuse." in: British journal of haematology, Vol. 93, Issue 1, pp. 131-8, (1996) (PubMed).

Jabado, Le Deist, Cant, De Graeff-Meeders, Fasth, Morgan, Vellodi, Hale, Bujan, Thomas, Cavazzana-Calvo, Wijdenes, Fischer: "Bone marrow transplantation from genetically HLA-nonidentical donors in children with fatal inherited disorders excluding severe combined immunodeficiencies: use of two monoclonal antibodies to prevent graft rejection." in: Pediatrics, Vol. 98, Issue 3 Pt 1, pp. 420-8, (1996) (PubMed).

Racadot, Milpied, Bordigoni, Cahn, Plouvier, Lioure, Lutz, Wijdenes, Herve: "Sequential use of three monoclonal antibodies in corticosteroid-resistant acute GVHD: a multicentric pilot study including 15 patients." in: Bone marrow transplantation, Vol. 15, Issue 5, pp. 669-77, (1995) (PubMed).

Target Details for CD2

Target: CD2

Alternative Name: CD2 (CD2 Products)

Synonyms: CD2 antibody, LFA-2 antibody, Ly-37 antibody, Ly37 antibody, SRBC antibody, T11 antibody, CD2R antibody, LFA2 antibody, OX-34 antibody, OX34 antibody, CD2 molecule antibody, CD2 antigen antibody, Cd2 molecule antibody, CD2 antibody, Cd2 antibody

Background: LFA-2

Molecular Weight: 50 kDa