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Influenza Nucleoprotein antibody (Influenza A Virus (A/Russia:St.Petersburg/8/2006)) (AA 71-170)

NP Reactivity: Influenza A Virus, Virus WB, IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1385576
  • Target See all Influenza Nucleoprotein (NP) Antibodies
    Influenza Nucleoprotein (NP)
    Binding Specificity
    • 14
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    AA 71-170
    Reactivity
    • 63
    • 40
    • 14
    • 13
    • 11
    • 3
    • 1
    • 1
    • 1
    Influenza A Virus, Virus
    Virus Strain
    A/Russia:St.Petersburg/8/2006
    Host
    • 85
    • 43
    • 4
    Rabbit
    Clonality
    • 87
    • 44
    Polyclonal
    Conjugate
    • 93
    • 10
    • 10
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 87
    • 57
    • 26
    • 15
    • 14
    • 13
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Virus
    Cross-Reactivity (Details)
    Influenza A virus
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1) Nucleoprotein
    Isotype
    IgG
    Top Product
    Discover our top product NP Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Chen, Angel, Li, Finch, Gonzalez, Sutton, Santos, Perez: "All-in-one bacmids: an efficient reverse genetics strategy for influenza A virus vaccines." in: Journal of virology, Vol. 88, Issue 17, pp. 10013-25, (2014) (PubMed).

  • Target
    Influenza Nucleoprotein (NP)
    Alternative Name
    Influenza A virus Nucleoprotein (NP Products)
    Synonyms
    nucleoprotein antibody, NP antibody
    Target Type
    Influenza Protein
    Background

    Synonyms: Nucleoprotein, NP, Nucleocapsid protein, Protein N, Influenza A virus H1N1, H3N2 Nucleoprotein, H9N2 Nucleoprotein, H2N2 Nucleoprotein, H3N8 Nucleoprotein, H7N7 Nucleoprotein, H5N1 Nucleoprotein.

    Background: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

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