TSPEAR antibody

Catalog No. ABIN1385728

Product Details anti-TSPEAR Antibody

Target: TSPEAR (Thrombospondin-Type Laminin G Domain and EAR Repeats (TSPEAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSPEAR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TSPEAR/C21orf9

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TSPEAR

Target: TSPEAR (Thrombospondin-Type Laminin G Domain and EAR Repeats (TSPEAR))

Alternative Name: TSPEAR (TSPEAR Products)

Synonyms: C330046G03Rik antibody, ORF65 antibody, TSP-EAR antibody, Tnep1 antibody, C21orf29 antibody, DFNB98 antibody, RGD1563108 antibody, thrombospondin type laminin G domain and EAR repeats antibody, thrombospondin-type laminin G domain and EAR repeats antibody, Tspear antibody, TSPEAR antibody

Background:

Synonyms: C21orf14, C21orf38, C21orf7, Chromosome 21 open reading frame 38, Chromosome 21 open reading frame 91, Early undferentiated retina and lens, EURL, Protein EURL homolog, YG81, TSEAR_HUMAN.

Background: TSPEAR, also known as C21orf9, is a 669 amino acid secreted protein. Expressed as two isoforms produced by alternative splicing, TSPEAR contains one Thrombospondin N-terminal domain and seven EAR (epilepsy-associated repeat) domains. EAR domains are found in several proteins, including TSPEAR, encoded by genes that map within chromosome regions associated with seizure disorders. It is thought that the EAR domain plays a role in the pathogenesis of epilepsy by either binding to an unknown epileptic ligand or interfering with axon synaptogenesis.

Pathways: Sensory Perception of Sound