NR4A3 antibody (AA 521-626)

Catalog No. ABIN1386602

The Rabbit Polyclonal anti-NR4A3 antibody has been validated for WB, ELISA, IF (cc), IF (p), FACS, ICC and IHC (fro). It is suitable to detect NR4A3 in samples from Human and Mouse.

Quick Overview for NR4A3 antibody (AA 521-626) (ABIN1386602)

Target: NR4A3 (Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR4A3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NR4A3 Antibody

Binding Specificity: AA 521-626

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NR4A3

Target: NR4A3 (Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3))

Alternative Name: NOR1

Background:

Synonyms: CHN, Chondrosarcoma, extraskeletal myxoid, fused to EWS, CSMF, MINOR, Mitogen induced nuclear orphan receptor, Mitogen-induced nuclear orphan receptor, Neuron derived orphan receptor 1, Neuron derived orphan receptor, Neuron-derived orphan receptor 1, NOR1, Nr4a3, NR4A3_HUMAN, Nuclear hormone receptor NOR-1, Nuclear hormone receptor NOR1, Nuclear receptor subfamily 4 group A member 3, TEC, Translocated in extraskeletal chondrosarcoma.

Background: Nur77 (also designated NGFI-B), Nurr1 (Nur-related factor 1), and NOR-1 (neuron-derived orphan receptor 1) constitute the NGFI-B subfamily within the nuclear receptor superfamily. Ligands for these protein have not been identified, and, therefore, they are designated orphan nuclear receptors?. Genes of the NGFI-B subfamily are classified as immediate-early genes, which are induced rapidly, but transiently, in response to a variety of stimuli. They have been implicated in cell proliferation, differentiation, and apoptosis. The human NOR-1 gene maps to chromosome 9q, and encodes a protein which is expressed in heart, skeletal muscle, thymus, and spleen as well as in brain, where it is developmentally regulated. There-fore, NOR-1 may be involved in regulating neural differentiation. The NOR-1 gene also undergoes chromosomal translocation with the EWS gene to produce a protein thought to affect pre-mRNA splicing.

Pathways: Fc-epsilon Receptor Signaling Pathway, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway