NR6A1 antibody (AA 251-350)

Catalog No. ABIN1387521

Product Details anti-NR6A1 Antibody

Target: NR6A1 (Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1))

Binding Specificity: AA 251-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR6A1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GCNF

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NR6A1

Target: NR6A1 (Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1))

Alternative Name: GCNF (NR6A1 Products)

Synonyms: GCNF antibody, GCNF1 antibody, NR61 antibody, RTR antibody, hGCNF antibody, hRTR antibody, 1700113M01Rik antibody, Gcnf antibody, NCNF antibody, gcnf antibody, xEmGCNF antibody, gcnf1 antibody, nr61 antibody, rtr antibody, xGCNF antibody, NR6A1 antibody, GCNF-B antibody, si:ch211-167p9.1 antibody, zC167P9.1 antibody, zgc:114189 antibody, nr6a1 antibody, zfGCNF antibody, nuclear receptor subfamily 6 group A member 1 antibody, nuclear receptor subfamily 6, group A, member 1 antibody, nuclear receptor subfamily 6 group A member 1 S homeolog antibody, nuclear receptor subfamily 6, group A, member 1b antibody, nuclear receptor subfamily 6, group A, member 1a antibody, NR6A1 antibody, Nr6a1 antibody, nr6a1.S antibody, nr6a1 antibody, nr6a1b antibody, nr6a1a antibody

Background:

Synonyms: GCNF 1, GCNF, GCNF1, Germ cell nuclear factor, hGCNF, hRTR, NR 61, NR61, NR6A1, NR6A1_HUMAN, Nuclear receptor subfamily 6 group A member 1, Orphan nuclear receptor NR6A1, Retinoic acid receptor related testis associated receptor, Retinoid receptor related testis specic receptor, Retinoid receptor-related testis-specic receptor, RTR.

Background: Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily that influences neurogenesis and germ cell development. GCNF can homodimerize and bind DNA. GCNF regulates paracrine interaction between the oocyte and somatic cells by regulating the expression of BMP-15 and GDF-9, to affect female fertility. GCNF is present in spermatocytes and round spermatids of adult male mouse testis, northern blot and ribonuclease protection assays have shown GCNF is predominant in the testis. The gene expresses three alternatively spliced transcript variants.

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway