O3FAR1 antibody (AA 21-120)

Catalog No. ABIN1387736

Product Details anti-O3FAR1 Antibody

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Binding Specificity: AA 21-120

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This O3FAR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human G protein coupled receptor 120

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-O3FAR1 antibody (ABIN1387736)

Meng, Yuan, Zhang, Zhang, Fu, Zhu, Shu, Wang, Gao, Xi, Sun, Zhang, Jiang, Wang: "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." in: Biochemical and biophysical research communications, Vol. 491, Issue 1, pp. 192-197, (2017) (PubMed).

Target Details for O3FAR1

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Alternative Name: GPR120 (O3FAR1 Products)

Synonyms: BMIQ10 antibody, GPR120 antibody, GPR129 antibody, GT01 antibody, O3FAR1 antibody, PGR4 antibody, AI552415 antibody, Gpr120 antibody, Gpr129 antibody, KPG_013 antibody, O3far1 antibody, Pgr4 antibody, free fatty acid receptor 4 antibody, phosphodiesterase 6C antibody, FFAR4 antibody, Ffar4 antibody, PDE6C antibody

Background:

Synonyms: G protein coupled receptor 120, GPCR GPR120, G protein coupled receptor 129, G protein coupled receptor GT01, G protein coupled receptor PGR 4, G protein coupled receptor PGR4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, GPR 120, GPR 129, GPR120, GPR129, GT01, HGNC:19345, MGC119984, O3FA1_HUMAN, O3FAR1, Omega-3 fatty acid receptor 1, PGR 4, PGR4, GPCR120.

Background: GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.

Gene ID: 338557

UniProt: Q5NUL3

Pathways: Hormone Transport