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ADAM12 antibody (AA 251-350)

ADAM12 Reactivity: Human, Mouse ELISA, WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1387748
  • Target See all ADAM12 Antibodies
    ADAM12 (ADAM Metallopeptidase Domain 12 (ADAM12))
    Binding Specificity
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-350
    Reactivity
    • 36
    • 17
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 25
    • 6
    • 3
    • 3
    Rabbit
    Clonality
    • 32
    • 5
    Polyclonal
    Conjugate
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADAM12 antibody is un-conjugated
    Application
    • 19
    • 16
    • 12
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Dog,Cow,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ADAM12/MLTN
    Isotype
    IgG
    Top Product
    Discover our top product ADAM12 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Branco, da Costa, Abe, Kataoka, Pinheiro, Alves Júnior: "HIF-1α, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma." in: Oral surgery, oral medicine, oral pathology and oral radiology, Vol. 127, Issue 1, pp. e8-e17, (2019) (PubMed).

  • Target
    ADAM12 (ADAM Metallopeptidase Domain 12 (ADAM12))
    Alternative Name
    ADAM12 (ADAM12 Products)
    Synonyms
    ADAM12 antibody, adam12 antibody, Mltna antibody, mKIAA4001 antibody, MCMP antibody, MCMPMltna antibody, MLTN antibody, MLTNA antibody, ADAM metallopeptidase domain 12 antibody, a disintegrin and metallopeptidase domain 12 (meltrin alpha) antibody, ADAM12 antibody, adam12 antibody, Adam12 antibody
    Background

    Synonyms: MLTN, A disintegrin and metalloproteinase domain 12, A disintegrin and metalloproteinase domain 12, ADA12_HUMAN, ADAM 12, ADAM metallopeptidase domain 12, ADAM12, Disintegrin and metalloproteinase domain-containing protein 12, MCMP, MCMPMltna, MCMPMltna, Meltrin alpha, Meltrin-alpha, MLTN, MLTNA, OTTHUMP00000046766.

    Background: ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNF?(tumor necrosis factor ?, and modulation of the neurogenic function of Notch and Delta (1-3). ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail (1-3). ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone, and muscle, and catalyze proteolysis, adhesion, fusion, and intracellular signaling (3). ADAM 12 (Meltrin-a) is produced as 2 differentially spliced isoforms, a 718 amino acid secreted form (ADAM12S) and a 881 amino acid membrane-bound form (ADAM12L), and is involved in egg-sperm fusion (4-6).

    Pathways
    EGFR Signaling Pathway
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