CELSR3 antibody (AA 1601-1700)

Catalog No. ABIN1387763

Product Details anti-CELSR3 Antibody

Target: CELSR3 (Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3))

Binding Specificity: AA 1601-1700

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CELSR3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Flamingo homolog 1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CELSR3 antibody (ABIN1387763)

Su, Zhang, Gan, Jiang, Xiao, Zou, Li, Jiang: "Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." in: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).

Target Details for CELSR3

Target: CELSR3 (Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3))

Alternative Name: CELSR3/Flamingo homolog 1 (CELSR3 Products)

Background:

Synonyms: Cadherin EGF LAG seven-pass G-type receptor 3, Cadherin family member 11, CDHF11, CELR3_HUMAN, CELSR3, EGF-like protein 1, EGFL1, Epidermal growth factor-like protein 1, Flamingo, Flamingo homolog 1, FMI1, HFMI1, MEGF2, Multiple EGF-like domains protein 2, Multiple epidermal growth factor-like domains protein 2.

Background: Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.

Gene ID: 1951

UniProt: Q9NYQ7