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Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy.
Synonyms: G2SYN, Gamma2-syntrophin, SNTG2, SYN5, Syntrophin-5, Syntrophin5, Syntrophin 5, Syntrophin gamma 2, SNTG2_HUMAN.