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C1QC antibody (AA 81-180) (Biotin)

C1QC Reactivity: Human, Mouse WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1390675
  • Target See all C1QC Antibodies
    C1QC (Complement Component 1, Q Subcomponent, C Chain (C1QC))
    Binding Specificity
    • 14
    • 9
    • 7
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 81-180
    Reactivity
    • 46
    • 19
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 43
    • 3
    Rabbit
    Clonality
    • 44
    • 2
    Polyclonal
    Conjugate
    • 19
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C1QC antibody is conjugated to Biotin
    Application
    • 40
    • 23
    • 22
    • 13
    • 13
    • 13
    • 12
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Dog,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human C1QC
    Isotype
    IgG
    Top Product
    Discover our top product C1QC Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    C1QC (Complement Component 1, Q Subcomponent, C Chain (C1QC))
    Alternative Name
    C1QC/C1QG (C1QC Products)
    Synonyms
    c1qc antibody, AI385742 antibody, C1qg antibody, Ciqc antibody, C1Q-C antibody, C1QG antibody, complement C1q C chain antibody, complement component 1, q subcomponent, C chain antibody, C1QC antibody, c1qc antibody, C1qc antibody
    Background

    Synonyms: C1Q C, C1qc, C1QC_HUMAN, C1QG, Complement C1q subcomponent subunit C, Complement component 1, q subcomponent, C chain, complement component 1, q subcomponent, gamma polypeptide, AI385742.

    Background: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA, as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorder characterized by lupus-like symptoms.

    Pathways
    Complement System
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